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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NME2
All Species:
47.27
Human Site:
S122
Identified Species:
80
UniProt:
P22392
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P22392
NP_001018146.1
152
17298
S122
N
I
I
H
G
S
D
S
V
K
S
A
E
K
E
Chimpanzee
Pan troglodytes
XP_001147407
308
33377
S278
N
I
I
H
G
S
D
S
V
K
T
A
E
K
E
Rhesus Macaque
Macaca mulatta
XP_001096144
240
26905
S210
N
I
I
H
G
S
D
S
V
E
S
A
E
K
E
Dog
Lupus familis
XP_533973
152
17223
S122
N
I
I
H
G
S
D
S
V
E
S
V
E
K
E
Cat
Felis silvestris
Mouse
Mus musculus
Q01768
152
17345
S122
N
I
I
H
G
S
D
S
V
E
S
A
E
K
E
Rat
Rattus norvegicus
P19804
152
17264
S122
N
I
I
H
G
S
D
S
V
E
S
A
E
K
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515701
267
30034
S237
N
I
I
H
G
S
D
S
V
K
S
A
E
K
E
Chicken
Gallus gallus
O57535
153
17269
S123
N
I
I
H
G
S
D
S
V
E
S
A
Q
K
E
Frog
Xenopus laevis
P70011
154
17484
S123
N
I
I
H
G
S
D
S
V
D
S
A
N
K
E
Zebra Danio
Brachydanio rerio
NP_571001
153
17215
S123
N
I
I
H
G
S
D
S
V
D
S
A
N
T
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P08879
153
17151
A123
N
I
I
H
G
S
D
A
V
E
S
A
E
K
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8LAH8
237
25755
G205
N
I
I
H
G
S
D
G
P
E
T
A
K
D
E
Baker's Yeast
Sacchar. cerevisiae
P36010
153
17148
S123
N
V
C
H
G
S
D
S
V
D
S
A
E
R
E
Red Bread Mold
Neurospora crassa
Q9UUY8
152
16882
S122
N
V
C
H
G
S
D
S
V
E
N
A
K
K
E
Conservation
Percent
Protein Identity:
100
46.4
57
84.8
N.A.
98
98
N.A.
54.3
91.5
86.3
86.9
N.A.
77.1
N.A.
N.A.
N.A.
Protein Similarity:
100
47.7
60.8
92.1
N.A.
99.3
99.3
N.A.
55.8
96
94.8
92.8
N.A.
86.2
N.A.
N.A.
N.A.
P-Site Identity:
100
93.3
93.3
86.6
N.A.
93.3
93.3
N.A.
100
86.6
86.6
80
N.A.
86.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
100
100
86.6
80
N.A.
100
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
40
60.1
63.1
Protein Similarity:
N.A.
N.A.
N.A.
51
79
79.6
P-Site Identity:
N.A.
N.A.
N.A.
60
73.3
66.6
P-Site Similarity:
N.A.
N.A.
N.A.
80
86.6
93.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
8
0
0
0
93
0
0
0
% A
% Cys:
0
0
15
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
100
0
0
22
0
0
0
8
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
58
0
0
65
0
100
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
100
0
0
8
0
0
0
0
0
0
0
% G
% His:
0
0
0
100
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
86
86
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
22
0
0
15
79
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
100
0
0
0
0
0
0
0
0
0
8
0
15
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% R
% Ser:
0
0
0
0
0
100
0
86
0
0
79
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
15
0
0
8
0
% T
% Val:
0
15
0
0
0
0
0
0
93
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _