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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ENPP1
All Species:
26.06
Human Site:
Y280
Identified Species:
57.33
UniProt:
P22413
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P22413
NP_006199.2
925
104924
Y280
G
I
I
D
N
K
M
Y
D
P
K
M
N
A
S
Chimpanzee
Pan troglodytes
XP_518743
925
104932
Y280
G
I
I
D
N
K
M
Y
D
P
K
M
N
A
S
Rhesus Macaque
Macaca mulatta
XP_001103359
925
105082
Y280
G
I
I
D
N
K
M
Y
D
P
K
M
N
A
S
Dog
Lupus familis
XP_533360
916
103904
Y271
G
I
I
D
N
K
I
Y
D
P
K
M
N
A
F
Cat
Felis silvestris
Mouse
Mus musculus
P06802
906
103157
Y262
G
I
I
D
N
K
M
Y
D
P
K
M
N
A
S
Rat
Rattus norvegicus
Q924C3
906
102924
Y262
G
I
I
D
N
K
M
Y
D
P
K
M
N
A
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505967
868
99060
A259
G
Q
P
I
W
L
T
A
M
Y
Q
G
L
K
A
Chicken
Gallus gallus
XP_424539
912
103729
Y263
G
I
I
D
N
K
M
Y
D
L
K
R
N
A
Y
Frog
Xenopus laevis
NP_001090160
874
99571
I260
R
W
W
G
G
Q
P
I
W
I
T
A
S
K
Q
Zebra Danio
Brachydanio rerio
Q566N0
459
51584
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P90754
829
93146
P221
D
K
V
Y
P
S
Y
P
S
K
T
F
P
N
H
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.7
98.3
86
N.A.
78.9
78.4
N.A.
49.9
65.4
43.6
21
N.A.
N.A.
N.A.
24
N.A.
Protein Similarity:
100
98.9
99.1
92.4
N.A.
87.7
87.7
N.A.
65.7
79.2
59.3
32.2
N.A.
N.A.
N.A.
40.4
N.A.
P-Site Identity:
100
100
100
86.6
N.A.
100
100
N.A.
6.6
80
0
0
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
20
80
13.3
0
N.A.
N.A.
N.A.
6.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
10
0
0
0
10
0
64
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
0
64
0
0
0
0
64
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
10
% F
% Gly:
73
0
0
10
10
0
0
0
0
0
0
10
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% H
% Ile:
0
64
64
10
0
0
10
10
0
10
0
0
0
0
0
% I
% Lys:
0
10
0
0
0
64
0
0
0
10
64
0
0
19
0
% K
% Leu:
0
0
0
0
0
10
0
0
0
10
0
0
10
0
0
% L
% Met:
0
0
0
0
0
0
55
0
10
0
0
55
0
0
0
% M
% Asn:
0
0
0
0
64
0
0
0
0
0
0
0
64
10
0
% N
% Pro:
0
0
10
0
10
0
10
10
0
55
0
0
10
0
0
% P
% Gln:
0
10
0
0
0
10
0
0
0
0
10
0
0
0
10
% Q
% Arg:
10
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% R
% Ser:
0
0
0
0
0
10
0
0
10
0
0
0
10
0
46
% S
% Thr:
0
0
0
0
0
0
10
0
0
0
19
0
0
0
0
% T
% Val:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
10
10
0
10
0
0
0
10
0
0
0
0
0
0
% W
% Tyr:
0
0
0
10
0
0
10
64
0
10
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _