Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FGFR4 All Species: 20
Human Site: S498 Identified Species: 40
UniProt: P22455 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P22455 NP_002002.3 802 87954 S498 P A R P D Q A S T V A V K M L
Chimpanzee Pan troglodytes XP_518127 807 88293 G526 S G P A L L A G L V S L D L P
Rhesus Macaque Macaca mulatta XP_001087243 802 87975 S498 P A R P D Q A S T V A V K M L
Dog Lupus familis XP_546211 858 94257 S555 P T Q P D Q A S T V A V K M L
Cat Felis silvestris
Mouse Mus musculus Q03142 799 88643 S495 P S R P D Q T S T V A V K M L
Rat Rattus norvegicus Q498D6 800 88690 S496 S S R P D Q T S T V A V K M L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P18460 806 89712 I497 K D K P N K A I T V A V K M L
Frog Xenopus laevis Q91743 828 93399 V521 K D R P E K P V T V A V K M L
Zebra Danio Brachydanio rerio Q90413 922 103447 A609 K E N Q D H M A T V A V K M L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q07407 729 82568 D451 M V K E G H T D D D I A S L V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q10656 1040 118938 I667 K E T E N N E I A V A V K K L
Sea Urchin Strong. purpuratus Q26614 972 110463 S668 I V C Q E K T S T V A V K M L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 89.2 97.3 86.7 N.A. 89.7 88.7 N.A. N.A. 61.5 63.8 56.4 N.A. 35.5 N.A. 30.9 34.2
Protein Similarity: 100 89.7 98.3 88.5 N.A. 92.5 91.6 N.A. N.A. 72.9 74.6 68.6 N.A. 52.1 N.A. 46.1 49.2
P-Site Identity: 100 13.3 100 86.6 N.A. 86.6 80 N.A. N.A. 60 60 53.3 N.A. 0 N.A. 33.3 53.3
P-Site Similarity: 100 33.3 100 93.3 N.A. 93.3 86.6 N.A. N.A. 80 73.3 60 N.A. 20 N.A. 40 66.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 17 0 9 0 0 42 9 9 0 84 9 0 0 0 % A
% Cys: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 17 0 0 50 0 0 9 9 9 0 0 9 0 0 % D
% Glu: 0 17 0 17 17 0 9 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 9 0 0 9 0 0 9 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 17 0 0 0 0 0 0 0 0 0 % H
% Ile: 9 0 0 0 0 0 0 17 0 0 9 0 0 0 0 % I
% Lys: 34 0 17 0 0 25 0 0 0 0 0 0 84 9 0 % K
% Leu: 0 0 0 0 9 9 0 0 9 0 0 9 0 17 84 % L
% Met: 9 0 0 0 0 0 9 0 0 0 0 0 0 75 0 % M
% Asn: 0 0 9 0 17 9 0 0 0 0 0 0 0 0 0 % N
% Pro: 34 0 9 59 0 0 9 0 0 0 0 0 0 0 9 % P
% Gln: 0 0 9 17 0 42 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 42 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 17 17 0 0 0 0 0 50 0 0 9 0 9 0 0 % S
% Thr: 0 9 9 0 0 0 34 0 75 0 0 0 0 0 0 % T
% Val: 0 17 0 0 0 0 0 9 0 92 0 84 0 0 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _