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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ALAS2 All Species: 31.82
Human Site: Y199 Identified Species: 63.64
UniProt: P22557 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P22557 NP_000023.2 587 64633 Y199 S V W C S N D Y L G M S R H P
Chimpanzee Pan troglodytes XP_528998 559 61798 K196 V K S F Q G R K K C H K S S Q
Rhesus Macaque Macaca mulatta XP_001093098 580 63864 G194 W C S N D Y L G M S R H P Q V
Dog Lupus familis XP_548619 587 65062 Y199 S V W C S N D Y L G M S R H P
Cat Felis silvestris
Mouse Mus musculus P08680 587 64735 Y199 S V W C S N D Y L G I S R H P
Rat Rattus norvegicus Q63147 587 64823 Y199 S V W C S N D Y L G I S R H P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510619 581 64480 Y193 S V W C S N D Y L G M S R H P
Chicken Gallus gallus P07997 635 69930 Y248 S V W C S N D Y L G M S R H P
Frog Xenopus laevis NP_001087499 609 66693 Y221 S V W C S N D Y L G M S R H P
Zebra Danio Brachydanio rerio Q9YHT4 583 63890 Y194 S V W C S N D Y L G M S R H P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P09950 548 59344 Q195 A V L S L L G Q K M K D L V I
Red Bread Mold Neurospora crassa Q7RVY5 629 67428 H195 L G M G R N K H V L E A M H T
Conservation
Percent
Protein Identity: 100 84.6 80.4 91.8 N.A. 90.1 88.7 N.A. 74.2 57.9 67.6 66 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 86.1 85.1 95 N.A. 93.8 92.8 N.A. 83.4 71.8 79.1 77.1 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 0 0 100 N.A. 93.3 93.3 N.A. 100 100 100 100 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 0 6.6 100 N.A. 100 100 N.A. 100 100 100 100 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 37.8 39.5
Protein Similarity: N.A. N.A. N.A. N.A. 57.7 55.4
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 13.3
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % A
% Cys: 0 9 0 67 0 0 0 0 0 9 0 0 0 0 0 % C
% Asp: 0 0 0 0 9 0 67 0 0 0 0 9 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % E
% Phe: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 9 0 9 0 9 9 9 0 67 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 9 0 0 9 9 0 75 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 17 0 0 0 9 % I
% Lys: 0 9 0 0 0 0 9 9 17 0 9 9 0 0 0 % K
% Leu: 9 0 9 0 9 9 9 0 67 9 0 0 9 0 0 % L
% Met: 0 0 9 0 0 0 0 0 9 9 50 0 9 0 0 % M
% Asn: 0 0 0 9 0 75 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 67 % P
% Gln: 0 0 0 0 9 0 0 9 0 0 0 0 0 9 9 % Q
% Arg: 0 0 0 0 9 0 9 0 0 0 9 0 67 0 0 % R
% Ser: 67 0 17 9 67 0 0 0 0 9 0 67 9 9 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % T
% Val: 9 75 0 0 0 0 0 0 9 0 0 0 0 9 9 % V
% Trp: 9 0 67 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 9 0 67 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _