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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FDXR All Species: 18.79
Human Site: T25 Identified Species: 31.79
UniProt: P22570 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P22570 NP_004101.2 491 53837 T25 R L P P A G S T P S F C H H F
Chimpanzee Pan troglodytes XP_001137746 494 53873 T25 R L P P A G S T P S F R H H F
Rhesus Macaque Macaca mulatta XP_001091261 492 53992 T25 R P P P A G S T P S F R H H L
Dog Lupus familis XP_533117 492 54038 T25 R P P P A G S T P S F R Q Q F
Cat Felis silvestris
Mouse Mus musculus Q61578 494 54184 T27 S P S R S T P T P G F C Q K F
Rat Rattus norvegicus P56522 494 54344 T27 L P S R S T P T P G F C K K F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513817 497 53440 F30 S L S R S A P F P G W C Q H L
Chicken Gallus gallus XP_001232923 471 51228 G25 R I C V V G S G P A G F Y T A
Frog Xenopus laevis NP_001088306 486 53595 S27 G V Q R P F S S V S H T P Q I
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V3T9 466 51334 P28 Q V I Q S T T P T K R I C I V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_790150 503 55169 T36 L S S Q S A S T P R V C I I G
Poplar Tree Populus trichocarpa XP_002301734 496 54084 S28 S L S F S T L S S N P L R V C
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_194962 483 53051 V27 R P L H V C I V G S G P A G F
Baker's Yeast Sacchar. cerevisiae P48360 493 56219 P25 V S I V G S G P S G F Y T A Y
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 91.3 97.7 89.8 N.A. 86.6 86.8 N.A. 76 65.9 66.1 N.A. N.A. 46.6 N.A. N.A. 52.8
Protein Similarity: 100 92.9 98.3 93.9 N.A. 91.3 92.1 N.A. 83.3 78.4 76.3 N.A. N.A. 62.5 N.A. N.A. 67.7
P-Site Identity: 100 93.3 80 73.3 N.A. 33.3 33.3 N.A. 26.6 26.6 13.3 N.A. N.A. 0 N.A. N.A. 26.6
P-Site Similarity: 100 93.3 80 73.3 N.A. 40 40 N.A. 40 46.6 26.6 N.A. N.A. 26.6 N.A. N.A. 33.3
Percent
Protein Identity: 47.5 N.A. N.A. 46.4 35.2 N.A.
Protein Similarity: 61 N.A. N.A. 60.9 54.9 N.A.
P-Site Identity: 6.6 N.A. N.A. 20 6.6 N.A.
P-Site Similarity: 26.6 N.A. N.A. 20 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 29 15 0 0 0 8 0 0 8 8 8 % A
% Cys: 0 0 8 0 0 8 0 0 0 0 0 36 8 0 8 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 8 0 8 0 8 0 0 50 8 0 0 43 % F
% Gly: 8 0 0 0 8 36 8 8 8 29 15 0 0 8 8 % G
% His: 0 0 0 8 0 0 0 0 0 0 8 0 22 29 0 % H
% Ile: 0 8 15 0 0 0 8 0 0 0 0 8 8 15 8 % I
% Lys: 0 0 0 0 0 0 0 0 0 8 0 0 8 15 0 % K
% Leu: 15 29 8 0 0 0 8 0 0 0 0 8 0 0 15 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % N
% Pro: 0 36 29 29 8 0 22 15 65 0 8 8 8 0 0 % P
% Gln: 8 0 8 15 0 0 0 0 0 0 0 0 22 15 0 % Q
% Arg: 43 0 0 29 0 0 0 0 0 8 8 22 8 0 0 % R
% Ser: 22 15 36 0 43 8 50 15 15 43 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 29 8 50 8 0 0 8 8 8 0 % T
% Val: 8 15 0 15 15 0 0 8 8 0 8 0 0 8 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 8 8 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _