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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IGFBP4 All Species: 22.12
Human Site: S112 Identified Species: 48.67
UniProt: P22692 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P22692 NP_001543.2 258 27934 S112 E I E A I Q E S L Q P S D K D
Chimpanzee Pan troglodytes XP_511475 258 27929 S112 E I E A I Q E S L Q P S D K D
Rhesus Macaque Macaca mulatta XP_001087426 331 37178 S116 Q V K I E R D S R E H E E P T
Dog Lupus familis XP_850184 451 47194 S305 E I E A I Q E S L Q P S D K D
Cat Felis silvestris
Mouse Mus musculus P47879 254 27788 S112 E I E A I Q E S L Q T S D K D
Rat Rattus norvegicus P21744 254 27726 S112 E I E A I Q E S L Q T S D K D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517173 141 15692 S32 A K L R A G S S S S I R M R S
Chicken Gallus gallus P49705 311 33520 D138 E P P A D N G D D R S E S I L
Frog Xenopus laevis Q5XHC5 281 30573 T119 G S S Q E R G T E L P E D Q S
Zebra Danio Brachydanio rerio Q9PTH3 276 30746 A114 D T E P T G S A E P R E V S G
Tiger Blowfish Takifugu rubipres NP_001139534 261 28881 A120 R E V E E N S A M D R Q D E I
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 34.7 55.8 N.A. 90.6 90.3 N.A. 41 36 37.3 35.1 56.7 N.A. N.A. N.A. N.A.
Protein Similarity: 100 100 47.1 56.3 N.A. 93.8 93.4 N.A. 44.9 49.5 50.1 47 71.6 N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 6.6 100 N.A. 93.3 93.3 N.A. 6.6 13.3 13.3 6.6 6.6 N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 53.3 100 N.A. 93.3 93.3 N.A. 13.3 20 33.3 20 26.6 N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 55 10 0 0 19 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 0 0 0 10 0 10 10 10 10 0 0 64 0 46 % D
% Glu: 55 10 55 10 28 0 46 0 19 10 0 37 10 10 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 10 0 0 0 0 19 19 0 0 0 0 0 0 0 10 % G
% His: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % H
% Ile: 0 46 0 10 46 0 0 0 0 0 10 0 0 10 10 % I
% Lys: 0 10 10 0 0 0 0 0 0 0 0 0 0 46 0 % K
% Leu: 0 0 10 0 0 0 0 0 46 10 0 0 0 0 10 % L
% Met: 0 0 0 0 0 0 0 0 10 0 0 0 10 0 0 % M
% Asn: 0 0 0 0 0 19 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 10 10 10 0 0 0 0 0 10 37 0 0 10 0 % P
% Gln: 10 0 0 10 0 46 0 0 0 46 0 10 0 10 0 % Q
% Arg: 10 0 0 10 0 19 0 0 10 10 19 10 0 10 0 % R
% Ser: 0 10 10 0 0 0 28 64 10 10 10 46 10 10 19 % S
% Thr: 0 10 0 0 10 0 0 10 0 0 19 0 0 0 10 % T
% Val: 0 10 10 0 0 0 0 0 0 0 0 0 10 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _