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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IGFBP4
All Species:
11.82
Human Site:
S129
Identified Species:
26
UniProt:
P22692
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P22692
NP_001543.2
258
27934
S129
D
H
P
N
N
S
F
S
P
C
S
A
H
D
R
Chimpanzee
Pan troglodytes
XP_511475
258
27929
S129
D
H
P
N
N
S
F
S
P
C
S
A
H
D
R
Rhesus Macaque
Macaca mulatta
XP_001087426
331
37178
S133
E
M
A
E
E
T
Y
S
P
K
I
F
R
P
K
Dog
Lupus familis
XP_850184
451
47194
S322
D
H
P
N
N
S
F
S
P
C
S
A
H
D
R
Cat
Felis silvestris
Mouse
Mus musculus
P47879
254
27788
N129
E
H
P
N
N
S
F
N
P
C
S
A
H
D
H
Rat
Rattus norvegicus
P21744
254
27726
N129
E
H
P
N
N
S
F
N
P
C
S
A
H
D
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517173
141
15692
T49
G
G
P
H
R
E
E
T
R
P
L
I
Q
G
S
Chicken
Gallus gallus
P49705
311
33520
G155
N
H
V
D
S
T
G
G
M
M
S
G
A
S
S
Frog
Xenopus laevis
Q5XHC5
281
30573
V136
M
L
V
D
N
N
L
V
A
G
P
A
V
P
G
Zebra Danio
Brachydanio rerio
Q9PTH3
276
30746
L131
Q
D
P
L
D
I
G
L
T
E
V
P
P
I
R
Tiger Blowfish
Takifugu rubipres
NP_001139534
261
28881
I137
E
H
P
N
N
S
N
I
R
C
S
P
Q
D
K
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
34.7
55.8
N.A.
90.6
90.3
N.A.
41
36
37.3
35.1
56.7
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
100
47.1
56.3
N.A.
93.8
93.4
N.A.
44.9
49.5
50.1
47
71.6
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
13.3
100
N.A.
80
80
N.A.
6.6
13.3
13.3
13.3
53.3
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
40
100
N.A.
93.3
93.3
N.A.
20
40
26.6
20
66.6
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
0
0
0
0
10
0
0
55
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
55
0
0
0
0
0
% C
% Asp:
28
10
0
19
10
0
0
0
0
0
0
0
0
55
0
% D
% Glu:
37
0
0
10
10
10
10
0
0
10
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
46
0
0
0
0
10
0
0
0
% F
% Gly:
10
10
0
0
0
0
19
10
0
10
0
10
0
10
10
% G
% His:
0
64
0
10
0
0
0
0
0
0
0
0
46
0
19
% H
% Ile:
0
0
0
0
0
10
0
10
0
0
10
10
0
10
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
19
% K
% Leu:
0
10
0
10
0
0
10
10
0
0
10
0
0
0
0
% L
% Met:
10
10
0
0
0
0
0
0
10
10
0
0
0
0
0
% M
% Asn:
10
0
0
55
64
10
10
19
0
0
0
0
0
0
0
% N
% Pro:
0
0
73
0
0
0
0
0
55
10
10
19
10
19
0
% P
% Gln:
10
0
0
0
0
0
0
0
0
0
0
0
19
0
0
% Q
% Arg:
0
0
0
0
10
0
0
0
19
0
0
0
10
0
37
% R
% Ser:
0
0
0
0
10
55
0
37
0
0
64
0
0
10
19
% S
% Thr:
0
0
0
0
0
19
0
10
10
0
0
0
0
0
0
% T
% Val:
0
0
19
0
0
0
0
10
0
0
10
0
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _