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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRKACB
All Species:
13.64
Human Site:
S290
Identified Species:
27.27
UniProt:
P22694
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P22694
NP_002722.1
351
40623
S290
G
N
L
K
N
G
V
S
D
I
K
T
H
K
W
Chimpanzee
Pan troglodytes
XP_001136448
346
40126
S285
G
N
L
K
N
G
V
S
D
I
K
T
H
K
W
Rhesus Macaque
Macaca mulatta
O62846
209
24077
V151
C
F
Y
A
A
Q
V
V
L
A
F
Q
Y
L
H
Dog
Lupus familis
XP_867543
351
40605
S290
G
N
L
K
N
G
V
S
D
I
K
T
H
K
W
Cat
Felis silvestris
Mouse
Mus musculus
P05132
351
40552
N290
G
N
L
K
N
G
V
N
D
I
K
N
H
K
W
Rat
Rattus norvegicus
P68182
351
40689
S290
G
N
L
K
N
G
V
S
D
I
K
T
H
K
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q6U1I9
432
48872
E349
G
A
K
E
D
F
T
E
I
K
N
H
I
F
F
Frog
Xenopus laevis
Q6GPN6
434
49096
E351
G
A
K
N
D
F
M
E
I
K
N
H
I
F
F
Zebra Danio
Brachydanio rerio
Q7ZTW4
433
48964
D347
K
R
L
G
F
T
D
D
F
T
E
I
K
N
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P12370
353
40820
N292
G
N
L
K
A
G
V
N
D
I
K
N
Q
K
W
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P21137
404
46327
A327
G
N
L
K
N
G
V
A
D
I
K
N
H
K
W
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P06245
380
44201
R316
G
N
L
Q
S
G
S
R
D
I
K
A
H
P
W
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.1
47.8
98.8
N.A.
92
96.8
N.A.
N.A.
35.6
35.2
34.4
N.A.
82.1
N.A.
66.3
N.A.
Protein Similarity:
100
98
54.1
99.1
N.A.
95.1
98
N.A.
N.A.
54.6
55
54.2
N.A.
89.8
N.A.
77.4
N.A.
P-Site Identity:
100
100
6.6
100
N.A.
86.6
100
N.A.
N.A.
6.6
6.6
6.6
N.A.
73.3
N.A.
86.6
N.A.
P-Site Similarity:
100
100
13.3
100
N.A.
93.3
100
N.A.
N.A.
26.6
26.6
13.3
N.A.
80
N.A.
93.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
46.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
65.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
60
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
17
0
9
17
0
0
9
0
9
0
9
0
0
0
% A
% Cys:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
17
0
9
9
67
0
0
0
0
0
0
% D
% Glu:
0
0
0
9
0
0
0
17
0
0
9
0
0
0
0
% E
% Phe:
0
9
0
0
9
17
0
0
9
0
9
0
0
17
17
% F
% Gly:
84
0
0
9
0
67
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
17
59
0
17
% H
% Ile:
0
0
0
0
0
0
0
0
17
67
0
9
17
0
0
% I
% Lys:
9
0
17
59
0
0
0
0
0
17
67
0
9
59
0
% K
% Leu:
0
0
75
0
0
0
0
0
9
0
0
0
0
9
0
% L
% Met:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% M
% Asn:
0
67
0
9
50
0
0
17
0
0
17
25
0
9
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% P
% Gln:
0
0
0
9
0
9
0
0
0
0
0
9
9
0
0
% Q
% Arg:
0
9
0
0
0
0
0
9
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
9
0
9
34
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
9
9
0
0
9
0
34
0
0
0
% T
% Val:
0
0
0
0
0
0
67
9
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
67
% W
% Tyr:
0
0
9
0
0
0
0
0
0
0
0
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _