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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRKACB
All Species:
26.36
Human Site:
S339
Identified Species:
52.73
UniProt:
P22694
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P22694
NP_002722.1
351
40623
S339
E
E
E
D
I
R
V
S
I
T
E
K
C
A
K
Chimpanzee
Pan troglodytes
XP_001136448
346
40126
S334
E
E
E
D
I
R
V
S
I
T
E
K
C
A
K
Rhesus Macaque
Macaca mulatta
O62846
209
24077
G200
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
Dog
Lupus familis
XP_867543
351
40605
S339
E
E
E
D
I
R
V
S
I
T
E
K
C
A
K
Cat
Felis silvestris
Mouse
Mus musculus
P05132
351
40552
S339
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
Rat
Rattus norvegicus
P68182
351
40689
S339
E
E
E
E
I
R
V
S
I
T
E
K
C
G
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q6U1I9
432
48872
S398
T
D
E
P
V
P
N
S
I
G
Q
S
P
D
S
Frog
Xenopus laevis
Q6GPN6
434
49096
S400
T
E
E
P
V
P
N
S
I
G
Q
S
P
D
S
Zebra Danio
Brachydanio rerio
Q7ZTW4
433
48964
V396
P
E
F
T
D
E
P
V
P
N
S
I
G
C
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P12370
353
40820
S341
E
E
E
A
L
R
I
S
S
T
E
K
C
A
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P21137
404
46327
T376
R
V
D
G
P
A
D
T
R
H
F
V
E
E
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P06245
380
44201
Y365
Y
P
E
E
Q
L
D
Y
G
I
Q
G
D
D
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.1
47.8
98.8
N.A.
92
96.8
N.A.
N.A.
35.6
35.2
34.4
N.A.
82.1
N.A.
66.3
N.A.
Protein Similarity:
100
98
54.1
99.1
N.A.
95.1
98
N.A.
N.A.
54.6
55
54.2
N.A.
89.8
N.A.
77.4
N.A.
P-Site Identity:
100
100
13.3
100
N.A.
80
86.6
N.A.
N.A.
20
26.6
6.6
N.A.
73.3
N.A.
0
N.A.
P-Site Similarity:
100
100
13.3
100
N.A.
86.6
93.3
N.A.
N.A.
40
40
6.6
N.A.
86.6
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
46.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
65.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
9
0
9
0
0
0
0
0
0
0
42
0
% A
% Cys:
0
0
0
0
0
0
9
0
0
0
0
0
50
9
0
% C
% Asp:
0
9
9
25
9
0
17
0
0
0
0
0
9
25
0
% D
% Glu:
50
67
75
25
0
9
0
0
0
0
59
0
9
9
0
% E
% Phe:
0
0
9
0
0
0
0
0
0
0
9
0
0
0
0
% F
% Gly:
9
0
0
9
0
0
0
9
9
17
0
9
9
17
0
% G
% His:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% H
% Ile:
0
0
0
0
42
0
9
0
59
9
0
9
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
50
0
0
50
% K
% Leu:
0
0
0
0
9
17
0
0
0
0
0
0
9
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
17
0
0
17
0
0
0
0
0
% N
% Pro:
9
9
0
17
9
17
9
0
9
9
0
0
17
0
17
% P
% Gln:
0
0
0
0
9
0
0
0
0
0
25
0
0
0
0
% Q
% Arg:
9
9
0
0
0
50
0
0
9
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
67
9
0
9
17
0
0
25
% S
% Thr:
17
0
9
9
9
0
0
9
9
42
0
0
0
0
0
% T
% Val:
0
9
0
0
17
0
42
9
0
0
0
9
0
0
9
% V
% Trp:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
0
0
0
0
9
0
0
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _