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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CA4 All Species: 23.94
Human Site: Y109 Identified Species: 52.67
UniProt: P22748 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P22748 NP_000708.1 312 35032 Y109 G G G L P A P Y Q A K Q L H L
Chimpanzee Pan troglodytes XP_001140977 312 35047 Y109 G G G L P A P Y Q A K Q L H L
Rhesus Macaque Macaca mulatta XP_001107970 420 45906 Y217 G G G L P A R Y Q A T Q L H L
Dog Lupus familis XP_537711 336 37808 Y133 G G G L S T Q Y R A L Q L H L
Cat Felis silvestris
Mouse Mus musculus Q64444 305 34333 Y108 G G D L P A R Y E A V Q L H L
Rat Rattus norvegicus P48284 309 35058 Y108 G G D L P T Q Y K A I Q L H L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_415893 316 36141 R112 I G G G G L K R K Y K A I E F
Frog Xenopus laevis NP_001121289 301 33404 Y112 G G G L S G T Y V A T Q F H F
Zebra Danio Brachydanio rerio Q92051 260 28659 H94 I Y R L R Q F H F H W G S S D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q10462 310 34843 Y111 G G G L K H R Y K L A Q F H L
Sea Urchin Strong. purpuratus XP_781482 303 33106 F116 G G G L N G T F R A V Q F H F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.7 64 64.8 N.A. 56.7 58.3 N.A. N.A. 40.1 34.9 31.4 N.A. N.A. N.A. 31 30.7
Protein Similarity: 100 99.3 68.3 77.6 N.A. 72.7 74.6 N.A. N.A. 55 53.8 44.8 N.A. N.A. N.A. 45.1 46.4
P-Site Identity: 100 100 86.6 66.6 N.A. 73.3 66.6 N.A. N.A. 20 53.3 6.6 N.A. N.A. N.A. 53.3 46.6
P-Site Similarity: 100 100 86.6 73.3 N.A. 80 73.3 N.A. N.A. 33.3 53.3 13.3 N.A. N.A. N.A. 60 60
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 37 0 0 0 73 10 10 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 19 0 0 0 0 0 0 0 0 0 0 0 10 % D
% Glu: 0 0 0 0 0 0 0 0 10 0 0 0 0 10 0 % E
% Phe: 0 0 0 0 0 0 10 10 10 0 0 0 28 0 28 % F
% Gly: 82 91 73 10 10 19 0 0 0 0 0 10 0 0 0 % G
% His: 0 0 0 0 0 10 0 10 0 10 0 0 0 82 0 % H
% Ile: 19 0 0 0 0 0 0 0 0 0 10 0 10 0 0 % I
% Lys: 0 0 0 0 10 0 10 0 28 0 28 0 0 0 0 % K
% Leu: 0 0 0 91 0 10 0 0 0 10 10 0 55 0 64 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 46 0 19 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 10 19 0 28 0 0 82 0 0 0 % Q
% Arg: 0 0 10 0 10 0 28 10 19 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 19 0 0 0 0 0 0 0 10 10 0 % S
% Thr: 0 0 0 0 0 19 19 0 0 0 19 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 10 0 19 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % W
% Tyr: 0 10 0 0 0 0 0 73 0 10 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _