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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ME2
All Species:
22.73
Human Site:
S106
Identified Species:
41.67
UniProt:
P23368
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P23368
NP_002387.1
584
65444
S106
I
L
Q
D
D
I
E
S
L
M
P
I
V
Y
T
Chimpanzee
Pan troglodytes
XP_001154897
584
65469
S106
I
L
Q
D
D
I
E
S
L
M
P
I
V
Y
T
Rhesus Macaque
Macaca mulatta
XP_001099883
959
105776
S106
I
L
Q
D
D
I
E
S
L
M
P
I
V
Y
T
Dog
Lupus familis
XP_849530
584
65328
S106
I
L
Q
D
D
I
E
S
L
M
P
I
V
Y
T
Cat
Felis silvestris
Mouse
Mus musculus
Q99KE1
589
65781
S106
I
L
Q
D
D
I
E
S
L
M
P
I
V
Y
T
Rat
Rattus norvegicus
P13697
572
63984
K96
V
L
M
S
N
V
E
K
F
M
P
I
V
Y
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509137
583
65380
S106
I
L
Q
D
D
I
E
S
L
M
P
I
V
Y
T
Chicken
Gallus gallus
NP_989634
557
61982
A98
Y
T
P
T
V
G
L
A
C
Q
H
Y
G
L
A
Frog
Xenopus laevis
NP_001082582
583
65390
H106
V
L
L
D
D
I
E
H
L
M
P
I
V
Y
T
Zebra Danio
Brachydanio rerio
NP_001003627
581
64913
A106
V
L
M
E
D
I
E
A
L
M
P
I
V
Y
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780686
581
64710
D109
V
M
C
N
H
I
T
D
M
M
P
I
V
Y
T
Poplar Tree
Populus trichocarpa
P34105
591
65205
E117
T
A
M
M
E
L
E
E
R
N
E
R
L
F
Y
Maize
Zea mays
P16243
636
69805
L100
S
V
A
S
G
Y
T
L
L
R
D
P
H
H
N
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
58.5
91.6
N.A.
88.2
54.2
N.A.
85.4
55.3
76.3
75
N.A.
N.A.
N.A.
N.A.
55.3
Protein Similarity:
100
99.8
60
96
N.A.
93.7
71.9
N.A.
92.2
70.8
86.8
87.3
N.A.
N.A.
N.A.
N.A.
72.6
P-Site Identity:
100
100
100
100
N.A.
100
53.3
N.A.
100
0
80
73.3
N.A.
N.A.
N.A.
N.A.
46.6
P-Site Similarity:
100
100
100
100
N.A.
100
73.3
N.A.
100
6.6
86.6
93.3
N.A.
N.A.
N.A.
N.A.
73.3
Percent
Protein Identity:
47.5
44
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
64.6
61.1
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
6.6
6.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
33.3
20
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
0
0
0
0
16
0
0
0
0
0
0
8
% A
% Cys:
0
0
8
0
0
0
0
0
8
0
0
0
0
0
0
% C
% Asp:
0
0
0
54
62
0
0
8
0
0
8
0
0
0
0
% D
% Glu:
0
0
0
8
8
0
77
8
0
0
8
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
8
0
0
0
0
8
0
% F
% Gly:
0
0
0
0
8
8
0
0
0
0
0
0
8
0
0
% G
% His:
0
0
0
0
8
0
0
8
0
0
8
0
8
8
0
% H
% Ile:
47
0
0
0
0
70
0
0
0
0
0
77
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% K
% Leu:
0
70
8
0
0
8
8
8
70
0
0
0
8
8
0
% L
% Met:
0
8
24
8
0
0
0
0
8
77
0
0
0
0
0
% M
% Asn:
0
0
0
8
8
0
0
0
0
8
0
0
0
0
8
% N
% Pro:
0
0
8
0
0
0
0
0
0
0
77
8
0
0
0
% P
% Gln:
0
0
47
0
0
0
0
0
0
8
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
8
8
0
8
0
0
0
% R
% Ser:
8
0
0
16
0
0
0
47
0
0
0
0
0
0
0
% S
% Thr:
8
8
0
8
0
0
16
0
0
0
0
0
0
0
77
% T
% Val:
31
8
0
0
8
8
0
0
0
0
0
0
77
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
8
0
0
0
0
0
8
0
77
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _