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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ME2
All Species:
10.61
Human Site:
S368
Identified Species:
19.44
UniProt:
P23368
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P23368
NP_002387.1
584
65444
S368
Y
Q
E
P
F
T
H
S
A
P
E
S
I
P
D
Chimpanzee
Pan troglodytes
XP_001154897
584
65469
S368
Y
Q
E
P
F
T
H
S
A
P
E
S
I
P
D
Rhesus Macaque
Macaca mulatta
XP_001099883
959
105776
P368
Y
Q
E
P
F
T
H
P
V
P
E
S
I
P
D
Dog
Lupus familis
XP_849530
584
65328
S368
H
Q
E
P
F
A
H
S
A
P
G
I
I
P
D
Cat
Felis silvestris
Mouse
Mus musculus
Q99KE1
589
65781
A368
N
Q
E
P
Y
A
H
A
A
P
E
S
I
P
A
Rat
Rattus norvegicus
P13697
572
63984
A355
T
E
E
K
E
V
F
A
H
E
H
E
E
M
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509137
583
65380
Q368
H
Q
E
A
F
A
H
Q
A
P
N
Q
V
P
S
Chicken
Gallus gallus
NP_989634
557
61982
R342
S
L
T
E
E
K
S
R
F
A
H
E
H
A
E
Frog
Xenopus laevis
NP_001082582
583
65390
S368
N
Q
E
L
F
A
H
S
A
P
E
K
P
V
I
Zebra Danio
Brachydanio rerio
NP_001003627
581
64913
N361
R
A
Y
E
T
D
S
N
Q
E
A
F
V
H
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780686
581
64710
E364
R
P
S
G
G
I
T
E
H
K
G
R
Y
A
H
Poplar Tree
Populus trichocarpa
P34105
591
65205
D373
R
K
K
I
W
L
T
D
S
K
G
L
I
V
S
Maize
Zea mays
P16243
636
69805
A392
G
E
A
G
T
G
I
A
E
L
I
A
L
E
I
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
58.5
91.6
N.A.
88.2
54.2
N.A.
85.4
55.3
76.3
75
N.A.
N.A.
N.A.
N.A.
55.3
Protein Similarity:
100
99.8
60
96
N.A.
93.7
71.9
N.A.
92.2
70.8
86.8
87.3
N.A.
N.A.
N.A.
N.A.
72.6
P-Site Identity:
100
100
86.6
73.3
N.A.
66.6
6.6
N.A.
46.6
0
53.3
0
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
100
86.6
80
N.A.
80
20
N.A.
60
6.6
53.3
13.3
N.A.
N.A.
N.A.
N.A.
0
Percent
Protein Identity:
47.5
44
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
64.6
61.1
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
6.6
0
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
33.3
26.6
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
8
0
31
0
24
47
8
8
8
0
16
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
8
0
8
0
0
0
0
0
0
31
% D
% Glu:
0
16
62
16
16
0
0
8
8
16
39
16
8
8
8
% E
% Phe:
0
0
0
0
47
0
8
0
8
0
0
8
0
0
0
% F
% Gly:
8
0
0
16
8
8
0
0
0
0
24
0
0
0
0
% G
% His:
16
0
0
0
0
0
54
0
16
0
16
0
8
8
8
% H
% Ile:
0
0
0
8
0
8
8
0
0
0
8
8
47
0
16
% I
% Lys:
0
8
8
8
0
8
0
0
0
16
0
8
0
0
8
% K
% Leu:
0
8
0
8
0
8
0
0
0
8
0
8
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
16
0
0
0
0
0
0
8
0
0
8
0
0
0
0
% N
% Pro:
0
8
0
39
0
0
0
8
0
54
0
0
8
47
8
% P
% Gln:
0
54
0
0
0
0
0
8
8
0
0
8
0
0
0
% Q
% Arg:
24
0
0
0
0
0
0
8
0
0
0
8
0
0
0
% R
% Ser:
8
0
8
0
0
0
16
31
8
0
0
31
0
0
16
% S
% Thr:
8
0
8
0
16
24
16
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
8
0
0
8
0
0
0
16
16
0
% V
% Trp:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
24
0
8
0
8
0
0
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _