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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ME2
All Species:
22.73
Human Site:
S560
Identified Species:
41.67
UniProt:
P23368
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P23368
NP_002387.1
584
65444
S560
V
K
E
R
T
W
R
S
E
Y
D
S
L
L
P
Chimpanzee
Pan troglodytes
XP_001154897
584
65469
S560
V
K
E
R
I
W
R
S
E
Y
D
S
L
L
P
Rhesus Macaque
Macaca mulatta
XP_001099883
959
105776
Q560
A
T
H
S
C
S
S
Q
L
I
R
G
F
H
F
Dog
Lupus familis
XP_849530
584
65328
S560
I
R
E
R
I
W
R
S
E
Y
D
S
L
L
P
Cat
Felis silvestris
Mouse
Mus musculus
Q99KE1
589
65781
S560
V
R
E
R
I
W
R
S
N
Y
V
S
L
L
P
Rat
Rattus norvegicus
P13697
572
63984
T547
V
S
S
Q
M
Y
S
T
N
Y
D
Q
I
L
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509137
583
65380
S560
V
R
S
R
I
W
R
S
D
Y
E
S
F
M
P
Chicken
Gallus gallus
NP_989634
557
61982
Y534
A
F
I
R
S
Q
M
Y
S
T
D
Y
N
S
F
Frog
Xenopus laevis
NP_001082582
583
65390
T560
I
R
S
K
V
W
N
T
D
Y
D
S
F
L
P
Zebra Danio
Brachydanio rerio
NP_001003627
581
64913
R553
V
D
K
E
S
Y
V
R
S
V
V
W
N
T
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780686
581
64710
R556
E
D
M
E
A
Y
V
R
K
C
V
Y
D
Y
E
Poplar Tree
Populus trichocarpa
P34105
591
65205
A565
K
A
Y
E
L
G
L
A
T
R
L
P
R
P
E
Maize
Zea mays
P16243
636
69805
P584
F
E
K
G
S
I
F
P
P
F
T
S
I
R
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
58.5
91.6
N.A.
88.2
54.2
N.A.
85.4
55.3
76.3
75
N.A.
N.A.
N.A.
N.A.
55.3
Protein Similarity:
100
99.8
60
96
N.A.
93.7
71.9
N.A.
92.2
70.8
86.8
87.3
N.A.
N.A.
N.A.
N.A.
72.6
P-Site Identity:
100
93.3
0
80
N.A.
73.3
33.3
N.A.
53.3
13.3
40
6.6
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
93.3
0
93.3
N.A.
80
60
N.A.
80
20
73.3
26.6
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
47.5
44
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
64.6
61.1
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
0
6.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
6.6
40
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
8
0
0
8
0
0
8
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
8
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
0
16
0
0
0
0
0
0
16
0
47
0
8
0
0
% D
% Glu:
8
8
31
24
0
0
0
0
24
0
8
0
0
0
16
% E
% Phe:
8
8
0
0
0
0
8
0
0
8
0
0
24
0
16
% F
% Gly:
0
0
0
8
0
8
0
0
0
0
0
8
0
0
0
% G
% His:
0
0
8
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
16
0
8
0
31
8
0
0
0
8
0
0
16
0
0
% I
% Lys:
8
16
16
8
0
0
0
0
8
0
0
0
0
0
8
% K
% Leu:
0
0
0
0
8
0
8
0
8
0
8
0
31
47
0
% L
% Met:
0
0
8
0
8
0
8
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
0
8
0
16
0
0
0
16
0
8
% N
% Pro:
0
0
0
0
0
0
0
8
8
0
0
8
0
8
54
% P
% Gln:
0
0
0
8
0
8
0
8
0
0
0
8
0
0
0
% Q
% Arg:
0
31
0
47
0
0
39
16
0
8
8
0
8
8
0
% R
% Ser:
0
8
24
8
24
8
16
39
16
0
0
54
0
8
0
% S
% Thr:
0
8
0
0
8
0
0
16
8
8
8
0
0
8
0
% T
% Val:
47
0
0
0
8
0
16
0
0
8
24
0
0
0
0
% V
% Trp:
0
0
0
0
0
47
0
0
0
0
0
8
0
0
0
% W
% Tyr:
0
0
8
0
0
24
0
8
0
54
0
16
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _