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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ME2 All Species: 18.79
Human Site: S575 Identified Species: 34.44
UniProt: P23368 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P23368 NP_002387.1 584 65444 S575 D V Y E W P E S A S S P P V I
Chimpanzee Pan troglodytes XP_001154897 584 65469 S575 D V Y E W P E S A S S P P M I
Rhesus Macaque Macaca mulatta XP_001099883 959 105776 K575 V H L I I K M K L S T G R P S
Dog Lupus familis XP_849530 584 65328 S575 D V Y D W P E S A L S P P L I
Cat Felis silvestris
Mouse Mus musculus Q99KE1 589 65781 S575 D V Y D W P E S S L T P P Q I
Rat Rattus norvegicus P13697 572 63984 E562 D C Y S W P E E V Q K I Q T K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509137 583 65380 A575 D V Y E W P E A A A K P P K F
Chicken Gallus gallus NP_989634 557 61982 P549 V A D S Y T W P E D A M K V K
Frog Xenopus laevis NP_001082582 583 65390 Y575 D L Y D W P E Y A S K P H K M
Zebra Danio Brachydanio rerio NP_001003627 581 64913 I568 Y D S F L P D I Y D W P G V S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_780686 581 64710 Y571 Y E S F T P D Y Y D W P T T E
Poplar Tree Populus trichocarpa P34105 591 65205 S580 N L V K H A E S C M Y S P A Y
Maize Zea mays P16243 636 69805 A599 I S A H I A A A V A G K A Y E
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 58.5 91.6 N.A. 88.2 54.2 N.A. 85.4 55.3 76.3 75 N.A. N.A. N.A. N.A. 55.3
Protein Similarity: 100 99.8 60 96 N.A. 93.7 71.9 N.A. 92.2 70.8 86.8 87.3 N.A. N.A. N.A. N.A. 72.6
P-Site Identity: 100 93.3 6.6 80 N.A. 66.6 33.3 N.A. 66.6 6.6 53.3 20 N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: 100 100 13.3 93.3 N.A. 86.6 33.3 N.A. 80 20 73.3 26.6 N.A. N.A. N.A. N.A. 20
Percent
Protein Identity: 47.5 44 N.A. N.A. N.A. N.A.
Protein Similarity: 64.6 61.1 N.A. N.A. N.A. N.A.
P-Site Identity: 20 0 N.A. N.A. N.A. N.A.
P-Site Similarity: 40 13.3 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 0 0 16 8 16 39 16 8 0 8 8 0 % A
% Cys: 0 8 0 0 0 0 0 0 8 0 0 0 0 0 0 % C
% Asp: 54 8 8 24 0 0 16 0 0 24 0 0 0 0 0 % D
% Glu: 0 8 0 24 0 0 62 8 8 0 0 0 0 0 16 % E
% Phe: 0 0 0 16 0 0 0 0 0 0 0 0 0 0 8 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 8 8 8 0 0 % G
% His: 0 8 0 8 8 0 0 0 0 0 0 0 8 0 0 % H
% Ile: 8 0 0 8 16 0 0 8 0 0 0 8 0 0 31 % I
% Lys: 0 0 0 8 0 8 0 8 0 0 24 8 8 16 16 % K
% Leu: 0 16 8 0 8 0 0 0 8 16 0 0 0 8 0 % L
% Met: 0 0 0 0 0 0 8 0 0 8 0 8 0 8 8 % M
% Asn: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 70 0 8 0 0 0 62 47 8 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 8 0 0 8 8 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % R
% Ser: 0 8 16 16 0 0 0 39 8 31 24 8 0 0 16 % S
% Thr: 0 0 0 0 8 8 0 0 0 0 16 0 8 16 0 % T
% Val: 16 39 8 0 0 0 0 0 16 0 0 0 0 24 0 % V
% Trp: 0 0 0 0 54 0 8 0 0 0 16 0 0 0 0 % W
% Tyr: 16 0 54 0 8 0 0 16 16 0 8 0 0 8 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _