KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ME2
All Species:
18.79
Human Site:
S575
Identified Species:
34.44
UniProt:
P23368
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P23368
NP_002387.1
584
65444
S575
D
V
Y
E
W
P
E
S
A
S
S
P
P
V
I
Chimpanzee
Pan troglodytes
XP_001154897
584
65469
S575
D
V
Y
E
W
P
E
S
A
S
S
P
P
M
I
Rhesus Macaque
Macaca mulatta
XP_001099883
959
105776
K575
V
H
L
I
I
K
M
K
L
S
T
G
R
P
S
Dog
Lupus familis
XP_849530
584
65328
S575
D
V
Y
D
W
P
E
S
A
L
S
P
P
L
I
Cat
Felis silvestris
Mouse
Mus musculus
Q99KE1
589
65781
S575
D
V
Y
D
W
P
E
S
S
L
T
P
P
Q
I
Rat
Rattus norvegicus
P13697
572
63984
E562
D
C
Y
S
W
P
E
E
V
Q
K
I
Q
T
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509137
583
65380
A575
D
V
Y
E
W
P
E
A
A
A
K
P
P
K
F
Chicken
Gallus gallus
NP_989634
557
61982
P549
V
A
D
S
Y
T
W
P
E
D
A
M
K
V
K
Frog
Xenopus laevis
NP_001082582
583
65390
Y575
D
L
Y
D
W
P
E
Y
A
S
K
P
H
K
M
Zebra Danio
Brachydanio rerio
NP_001003627
581
64913
I568
Y
D
S
F
L
P
D
I
Y
D
W
P
G
V
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780686
581
64710
Y571
Y
E
S
F
T
P
D
Y
Y
D
W
P
T
T
E
Poplar Tree
Populus trichocarpa
P34105
591
65205
S580
N
L
V
K
H
A
E
S
C
M
Y
S
P
A
Y
Maize
Zea mays
P16243
636
69805
A599
I
S
A
H
I
A
A
A
V
A
G
K
A
Y
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
58.5
91.6
N.A.
88.2
54.2
N.A.
85.4
55.3
76.3
75
N.A.
N.A.
N.A.
N.A.
55.3
Protein Similarity:
100
99.8
60
96
N.A.
93.7
71.9
N.A.
92.2
70.8
86.8
87.3
N.A.
N.A.
N.A.
N.A.
72.6
P-Site Identity:
100
93.3
6.6
80
N.A.
66.6
33.3
N.A.
66.6
6.6
53.3
20
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
100
13.3
93.3
N.A.
86.6
33.3
N.A.
80
20
73.3
26.6
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
47.5
44
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
64.6
61.1
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
20
0
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
40
13.3
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
0
0
16
8
16
39
16
8
0
8
8
0
% A
% Cys:
0
8
0
0
0
0
0
0
8
0
0
0
0
0
0
% C
% Asp:
54
8
8
24
0
0
16
0
0
24
0
0
0
0
0
% D
% Glu:
0
8
0
24
0
0
62
8
8
0
0
0
0
0
16
% E
% Phe:
0
0
0
16
0
0
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
8
8
8
0
0
% G
% His:
0
8
0
8
8
0
0
0
0
0
0
0
8
0
0
% H
% Ile:
8
0
0
8
16
0
0
8
0
0
0
8
0
0
31
% I
% Lys:
0
0
0
8
0
8
0
8
0
0
24
8
8
16
16
% K
% Leu:
0
16
8
0
8
0
0
0
8
16
0
0
0
8
0
% L
% Met:
0
0
0
0
0
0
8
0
0
8
0
8
0
8
8
% M
% Asn:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
70
0
8
0
0
0
62
47
8
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
8
0
0
8
8
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% R
% Ser:
0
8
16
16
0
0
0
39
8
31
24
8
0
0
16
% S
% Thr:
0
0
0
0
8
8
0
0
0
0
16
0
8
16
0
% T
% Val:
16
39
8
0
0
0
0
0
16
0
0
0
0
24
0
% V
% Trp:
0
0
0
0
54
0
8
0
0
0
16
0
0
0
0
% W
% Tyr:
16
0
54
0
8
0
0
16
16
0
8
0
0
8
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _