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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ME2 All Species: 14.52
Human Site: S578 Identified Species: 26.63
UniProt: P23368 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P23368 NP_002387.1 584 65444 S578 E W P E S A S S P P V I T E _
Chimpanzee Pan troglodytes XP_001154897 584 65469 S578 E W P E S A S S P P M I T E _
Rhesus Macaque Macaca mulatta XP_001099883 959 105776 T578 I I K M K L S T G R P S P P D
Dog Lupus familis XP_849530 584 65328 S578 D W P E S A L S P P L I T E _
Cat Felis silvestris
Mouse Mus musculus Q99KE1 589 65781 T578 D W P E S S L T P P Q I T E E
Rat Rattus norvegicus P13697 572 63984 K565 S W P E E V Q K I Q T K V N Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509137 583 65380
Chicken Gallus gallus NP_989634 557 61982
Frog Xenopus laevis NP_001082582 583 65390
Zebra Danio Brachydanio rerio NP_001003627 581 64913 W571 F L P D I Y D W P G V S H T P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_780686 581 64710 W574 F T P D Y Y D W P T T E S K Y
Poplar Tree Populus trichocarpa P34105 591 65205 Y583 K H A E S C M Y S P A Y R Y Y
Maize Zea mays P16243 636 69805 G602 H I A A A V A G K A Y E L G L
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 58.5 91.6 N.A. 88.2 54.2 N.A. 85.4 55.3 76.3 75 N.A. N.A. N.A. N.A. 55.3
Protein Similarity: 100 99.8 60 96 N.A. 93.7 71.9 N.A. 92.2 70.8 86.8 87.3 N.A. N.A. N.A. N.A. 72.6
P-Site Identity: 100 92.8 6.6 78.5 N.A. 60 20 N.A. 0 0 0 20 N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: 100 100 13.3 92.8 N.A. 80 20 N.A. 0 0 0 26.6 N.A. N.A. N.A. N.A. 40
Percent
Protein Identity: 47.5 44 N.A. N.A. N.A. N.A.
Protein Similarity: 64.6 61.1 N.A. N.A. N.A. N.A.
P-Site Identity: 20 0 N.A. N.A. N.A. N.A.
P-Site Similarity: 33.3 13.3 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 16 8 8 24 8 0 0 8 8 0 0 0 0 % A
% Cys: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % C
% Asp: 16 0 0 16 0 0 16 0 0 0 0 0 0 0 8 % D
% Glu: 16 0 0 47 8 0 0 0 0 0 0 16 0 31 8 % E
% Phe: 16 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 8 8 8 0 0 0 8 0 % G
% His: 8 8 0 0 0 0 0 0 0 0 0 0 8 0 0 % H
% Ile: 8 16 0 0 8 0 0 0 8 0 0 31 0 0 0 % I
% Lys: 8 0 8 0 8 0 0 8 8 0 0 8 0 8 0 % K
% Leu: 0 8 0 0 0 8 16 0 0 0 8 0 8 0 8 % L
% Met: 0 0 0 8 0 0 8 0 0 0 8 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % N
% Pro: 0 0 54 0 0 0 0 0 47 39 8 0 8 8 8 % P
% Gln: 0 0 0 0 0 0 8 0 0 8 8 0 0 0 8 % Q
% Arg: 0 0 0 0 0 0 0 0 0 8 0 0 8 0 0 % R
% Ser: 8 0 0 0 39 8 24 24 8 0 0 16 8 0 0 % S
% Thr: 0 8 0 0 0 0 0 16 0 8 16 0 31 8 0 % T
% Val: 0 0 0 0 0 16 0 0 0 0 16 0 8 0 0 % V
% Trp: 0 39 0 0 0 0 0 16 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 16 0 8 0 0 8 8 0 8 16 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 24 % _