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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ME2 All Species: 34.85
Human Site: T228 Identified Species: 63.89
UniProt: P23368 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P23368 NP_002387.1 584 65444 T228 L Y Q K R D R T Q Q Y D D L I
Chimpanzee Pan troglodytes XP_001154897 584 65469 T228 L Y Q K R D R T Q Q Y D D L I
Rhesus Macaque Macaca mulatta XP_001099883 959 105776 T228 L Y Q K R D R T Q Q Y D D L I
Dog Lupus familis XP_849530 584 65328 S228 L Y Q K R D R S Q R Y D D L I
Cat Felis silvestris
Mouse Mus musculus Q99KE1 589 65781 S228 L Y Q K R D R S Q L Y D D L M
Rat Rattus norvegicus P13697 572 63984 G218 L R H R R V R G P E Y D A F L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509137 583 65380 S228 L Y Q K R D R S Q R Y D D L I
Chicken Gallus gallus NP_989634 557 61982 D215 Q A Y D D L L D E F M E A V T
Frog Xenopus laevis NP_001082582 583 65390 T228 L Y Q K R D R T Q L Y D E L I
Zebra Danio Brachydanio rerio NP_001003627 581 64913 S228 L Y Q R R D R S Q R Y D D L I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_780686 581 64710 S231 L K D K R D R S E S Y D E L I
Poplar Tree Populus trichocarpa P34105 591 65205 L239 V G T N N E Q L L K D E F Y I
Maize Zea mays P16243 636 69805 G245 I L G L G D L G C Q G M G I P
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 58.5 91.6 N.A. 88.2 54.2 N.A. 85.4 55.3 76.3 75 N.A. N.A. N.A. N.A. 55.3
Protein Similarity: 100 99.8 60 96 N.A. 93.7 71.9 N.A. 92.2 70.8 86.8 87.3 N.A. N.A. N.A. N.A. 72.6
P-Site Identity: 100 100 100 86.6 N.A. 80 33.3 N.A. 86.6 0 86.6 80 N.A. N.A. N.A. N.A. 60
P-Site Similarity: 100 100 100 100 N.A. 93.3 53.3 N.A. 100 20 93.3 100 N.A. N.A. N.A. N.A. 80
Percent
Protein Identity: 47.5 44 N.A. N.A. N.A. N.A.
Protein Similarity: 64.6 61.1 N.A. N.A. N.A. N.A.
P-Site Identity: 6.6 13.3 N.A. N.A. N.A. N.A.
P-Site Similarity: 40 26.6 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 0 0 0 0 0 0 0 0 16 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % C
% Asp: 0 0 8 8 8 77 0 8 0 0 8 77 54 0 0 % D
% Glu: 0 0 0 0 0 8 0 0 16 8 0 16 16 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 8 0 0 8 8 0 % F
% Gly: 0 8 8 0 8 0 0 16 0 0 8 0 8 0 0 % G
% His: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 0 0 0 0 0 0 0 0 0 0 0 0 8 70 % I
% Lys: 0 8 0 62 0 0 0 0 0 8 0 0 0 0 0 % K
% Leu: 77 8 0 8 0 8 16 8 8 16 0 0 0 70 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 8 8 0 0 8 % M
% Asn: 0 0 0 8 8 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 8 % P
% Gln: 8 0 62 0 0 0 8 0 62 31 0 0 0 0 0 % Q
% Arg: 0 8 0 16 77 0 77 0 0 24 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 39 0 8 0 0 0 0 0 % S
% Thr: 0 0 8 0 0 0 0 31 0 0 0 0 0 0 8 % T
% Val: 8 0 0 0 0 8 0 0 0 0 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 62 8 0 0 0 0 0 0 0 77 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _