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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ME2 All Species: 26.67
Human Site: T376 Identified Species: 48.89
UniProt: P23368 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P23368 NP_002387.1 584 65444 T376 A P E S I P D T F E D A V N I
Chimpanzee Pan troglodytes XP_001154897 584 65469 T376 A P E S I P D T F E D A V N I
Rhesus Macaque Macaca mulatta XP_001099883 959 105776 T376 V P E S I P D T F E D A V N I
Dog Lupus familis XP_849530 584 65328 T376 A P G I I P D T F E D A V N I
Cat Felis silvestris
Mouse Mus musculus Q99KE1 589 65781 T376 A P E S I P A T F E D A V N K
Rat Rattus norvegicus P13697 572 63984 N363 H E H E E M K N L E A I V Q K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509137 583 65380 T376 A P N Q V P S T F E D A V N V
Chicken Gallus gallus NP_989634 557 61982 M350 F A H E H A E M R N L E D I V
Frog Xenopus laevis NP_001082582 583 65390 S376 A P E K P V I S F L D A V K V
Zebra Danio Brachydanio rerio NP_001003627 581 64913 D369 Q E A F V H P D P G D V K S F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_780686 581 64710 E372 H K G R Y A H E H K D L T D L
Poplar Tree Populus trichocarpa P34105 591 65205 S381 S K G L I V S S R K E S L Q H
Maize Zea mays P16243 636 69805 S400 E L I A L E I S K Q T N A P I
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 58.5 91.6 N.A. 88.2 54.2 N.A. 85.4 55.3 76.3 75 N.A. N.A. N.A. N.A. 55.3
Protein Similarity: 100 99.8 60 96 N.A. 93.7 71.9 N.A. 92.2 70.8 86.8 87.3 N.A. N.A. N.A. N.A. 72.6
P-Site Identity: 100 100 93.3 86.6 N.A. 86.6 13.3 N.A. 66.6 0 46.6 6.6 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 100 93.3 86.6 N.A. 86.6 13.3 N.A. 80 13.3 60 20 N.A. N.A. N.A. N.A. 26.6
Percent
Protein Identity: 47.5 44 N.A. N.A. N.A. N.A.
Protein Similarity: 64.6 61.1 N.A. N.A. N.A. N.A.
P-Site Identity: 6.6 6.6 N.A. N.A. N.A. N.A.
P-Site Similarity: 46.6 33.3 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 47 8 8 8 0 16 8 0 0 0 8 54 8 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 31 8 0 0 70 0 8 8 0 % D
% Glu: 8 16 39 16 8 8 8 8 0 54 8 8 0 0 0 % E
% Phe: 8 0 0 8 0 0 0 0 54 0 0 0 0 0 8 % F
% Gly: 0 0 24 0 0 0 0 0 0 8 0 0 0 0 0 % G
% His: 16 0 16 0 8 8 8 0 8 0 0 0 0 0 8 % H
% Ile: 0 0 8 8 47 0 16 0 0 0 0 8 0 8 39 % I
% Lys: 0 16 0 8 0 0 8 0 8 16 0 0 8 8 16 % K
% Leu: 0 8 0 8 8 0 0 0 8 8 8 8 8 0 8 % L
% Met: 0 0 0 0 0 8 0 8 0 0 0 0 0 0 0 % M
% Asn: 0 0 8 0 0 0 0 8 0 8 0 8 0 47 0 % N
% Pro: 0 54 0 0 8 47 8 0 8 0 0 0 0 8 0 % P
% Gln: 8 0 0 8 0 0 0 0 0 8 0 0 0 16 0 % Q
% Arg: 0 0 0 8 0 0 0 0 16 0 0 0 0 0 0 % R
% Ser: 8 0 0 31 0 0 16 24 0 0 0 8 0 8 0 % S
% Thr: 0 0 0 0 0 0 0 47 0 0 8 0 8 0 0 % T
% Val: 8 0 0 0 16 16 0 0 0 0 0 8 62 0 24 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _