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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ME2 All Species: 30.61
Human Site: T437 Identified Species: 56.11
UniProt: P23368 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P23368 NP_002387.1 584 65444 T437 A E E A Y T L T E G R C L F A
Chimpanzee Pan troglodytes XP_001154897 584 65469 T437 A E E A Y T L T E G R C L F A
Rhesus Macaque Macaca mulatta XP_001099883 959 105776 T437 A E E A Y T L T E G R C L F A
Dog Lupus familis XP_849530 584 65328 T437 A E E A Y T L T E G R C L F A
Cat Felis silvestris
Mouse Mus musculus Q99KE1 589 65781 T437 A E D A Y T L T E G R C L F A
Rat Rattus norvegicus P13697 572 63984 T424 A E E C Y K V T K G R A I F A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509137 583 65380 T437 A E E A Y T L T E G R C L F A
Chicken Gallus gallus NP_989634 557 61982 K411 C T A E Q C Y K Y T E G R G I
Frog Xenopus laevis NP_001082582 583 65390 T437 A E E A Y T W T E G Q C L F A
Zebra Danio Brachydanio rerio NP_001003627 581 64913 E430 A K A E C T A E D A Y S L T Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_780686 581 64710 E433 S K A E C T A E Q A Y T H T N
Poplar Tree Populus trichocarpa P34105 591 65205 I442 S F N E K P L I L A L S N P T
Maize Zea mays P16243 636 69805 I461 S I K P T V L I G T S G V G R
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 58.5 91.6 N.A. 88.2 54.2 N.A. 85.4 55.3 76.3 75 N.A. N.A. N.A. N.A. 55.3
Protein Similarity: 100 99.8 60 96 N.A. 93.7 71.9 N.A. 92.2 70.8 86.8 87.3 N.A. N.A. N.A. N.A. 72.6
P-Site Identity: 100 100 100 100 N.A. 93.3 60 N.A. 100 0 86.6 20 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 80 N.A. 100 0 93.3 33.3 N.A. N.A. N.A. N.A. 26.6
Percent
Protein Identity: 47.5 44 N.A. N.A. N.A. N.A.
Protein Similarity: 64.6 61.1 N.A. N.A. N.A. N.A.
P-Site Identity: 6.6 6.6 N.A. N.A. N.A. N.A.
P-Site Similarity: 13.3 26.6 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 70 0 24 54 0 0 16 0 0 24 0 8 0 0 62 % A
% Cys: 8 0 0 8 16 8 0 0 0 0 0 54 0 0 0 % C
% Asp: 0 0 8 0 0 0 0 0 8 0 0 0 0 0 0 % D
% Glu: 0 62 54 31 0 0 0 16 54 0 8 0 0 0 0 % E
% Phe: 0 8 0 0 0 0 0 0 0 0 0 0 0 62 0 % F
% Gly: 0 0 0 0 0 0 0 0 8 62 0 16 0 16 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % H
% Ile: 0 8 0 0 0 0 0 16 0 0 0 0 8 0 8 % I
% Lys: 0 16 8 0 8 8 0 8 8 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 62 0 8 0 8 0 62 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 8 0 0 0 0 0 0 0 0 0 8 0 8 % N
% Pro: 0 0 0 8 0 8 0 0 0 0 0 0 0 8 0 % P
% Gln: 0 0 0 0 8 0 0 0 8 0 8 0 0 0 8 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 54 0 8 0 8 % R
% Ser: 24 0 0 0 0 0 0 0 0 0 8 16 0 0 0 % S
% Thr: 0 8 0 0 8 70 0 62 0 16 0 8 0 16 8 % T
% Val: 0 0 0 0 0 8 8 0 0 0 0 0 8 0 0 % V
% Trp: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 62 0 8 0 8 0 16 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _