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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ME2
All Species:
18.79
Human Site:
T461
Identified Species:
34.44
UniProt:
P23368
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P23368
NP_002387.1
584
65444
T461
L
T
D
G
R
V
F
T
P
G
Q
G
N
N
V
Chimpanzee
Pan troglodytes
XP_001154897
584
65469
T461
L
T
D
G
R
V
F
T
P
G
Q
G
N
N
V
Rhesus Macaque
Macaca mulatta
XP_001099883
959
105776
T461
L
T
D
G
R
V
F
T
P
G
Q
G
N
N
V
Dog
Lupus familis
XP_849530
584
65328
T461
L
S
D
G
Q
L
F
T
P
G
Q
G
N
N
V
Cat
Felis silvestris
Mouse
Mus musculus
Q99KE1
589
65781
T461
L
Q
D
G
R
V
F
T
P
G
Q
G
N
N
A
Rat
Rattus norvegicus
P13697
572
63984
F448
L
P
D
G
R
T
L
F
P
G
Q
G
N
N
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509137
583
65380
I461
L
S
D
G
R
S
F
I
P
G
Q
G
N
N
A
Chicken
Gallus gallus
NP_989634
557
61982
T435
V
T
L
P
N
G
K
T
L
Y
P
G
Q
G
N
Frog
Xenopus laevis
NP_001082582
583
65390
K461
F
S
D
G
R
S
F
K
P
G
Q
G
N
N
A
Zebra Danio
Brachydanio rerio
NP_001003627
581
64913
E454
P
F
A
P
V
S
L
E
D
G
R
I
L
T
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780686
581
64710
P457
P
F
D
P
F
T
L
P
N
G
K
T
L
I
P
Poplar Tree
Populus trichocarpa
P34105
591
65205
K466
A
Y
T
W
T
K
G
K
A
I
F
A
S
G
S
Maize
Zea mays
P16243
636
69805
P485
M
S
S
F
N
E
R
P
I
I
F
S
L
S
N
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
58.5
91.6
N.A.
88.2
54.2
N.A.
85.4
55.3
76.3
75
N.A.
N.A.
N.A.
N.A.
55.3
Protein Similarity:
100
99.8
60
96
N.A.
93.7
71.9
N.A.
92.2
70.8
86.8
87.3
N.A.
N.A.
N.A.
N.A.
72.6
P-Site Identity:
100
100
100
80
N.A.
86.6
66.6
N.A.
73.3
20
66.6
6.6
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
100
100
100
N.A.
86.6
66.6
N.A.
80
26.6
73.3
13.3
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
47.5
44
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
64.6
61.1
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
0
0
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
6.6
20
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
0
0
0
0
0
8
0
0
8
0
0
24
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
70
0
0
0
0
0
8
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
8
0
8
0
0
0
0
0
0
0
% E
% Phe:
8
16
0
8
8
0
54
8
0
0
16
0
0
0
0
% F
% Gly:
0
0
0
62
0
8
8
0
0
77
0
70
0
16
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
8
8
16
0
8
0
8
0
% I
% Lys:
0
0
0
0
0
8
8
16
0
0
8
0
0
0
0
% K
% Leu:
54
0
8
0
0
8
24
0
8
0
0
0
24
0
0
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
16
0
0
0
8
0
0
0
62
62
16
% N
% Pro:
16
8
0
24
0
0
0
16
62
0
8
0
0
0
16
% P
% Gln:
0
8
0
0
8
0
0
0
0
0
62
0
8
0
0
% Q
% Arg:
0
0
0
0
54
0
8
0
0
0
8
0
0
0
0
% R
% Ser:
0
31
8
0
0
24
0
0
0
0
0
8
8
8
16
% S
% Thr:
0
31
8
0
8
16
0
47
0
0
0
8
0
8
0
% T
% Val:
8
0
0
0
8
31
0
0
0
0
0
0
0
0
31
% V
% Trp:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
0
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _