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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ME2
All Species:
3.94
Human Site:
T557
Identified Species:
7.22
UniProt:
P23368
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P23368
NP_002387.1
584
65444
T557
A
K
Y
V
K
E
R
T
W
R
S
E
Y
D
S
Chimpanzee
Pan troglodytes
XP_001154897
584
65469
I557
A
K
Y
V
K
E
R
I
W
R
S
E
Y
D
S
Rhesus Macaque
Macaca mulatta
XP_001099883
959
105776
C557
C
S
G
A
T
H
S
C
S
S
Q
L
I
R
G
Dog
Lupus familis
XP_849530
584
65328
I557
A
K
Y
I
R
E
R
I
W
R
S
E
Y
D
S
Cat
Felis silvestris
Mouse
Mus musculus
Q99KE1
589
65781
I557
A
R
Y
V
R
E
R
I
W
R
S
N
Y
V
S
Rat
Rattus norvegicus
P13697
572
63984
M544
E
E
F
V
S
S
Q
M
Y
S
T
N
Y
D
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509137
583
65380
I557
N
Q
Y
V
R
S
R
I
W
R
S
D
Y
E
S
Chicken
Gallus gallus
NP_989634
557
61982
S531
D
L
E
A
F
I
R
S
Q
M
Y
S
T
D
Y
Frog
Xenopus laevis
NP_001082582
583
65390
V557
K
A
Y
I
R
S
K
V
W
N
T
D
Y
D
S
Zebra Danio
Brachydanio rerio
NP_001003627
581
64913
S550
P
E
P
V
D
K
E
S
Y
V
R
S
V
V
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780686
581
64710
A553
P
R
P
E
D
M
E
A
Y
V
R
K
C
V
Y
Poplar Tree
Populus trichocarpa
P34105
591
65205
L562
V
A
A
K
A
Y
E
L
G
L
A
T
R
L
P
Maize
Zea mays
P16243
636
69805
S581
Q
D
N
F
E
K
G
S
I
F
P
P
F
T
S
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
58.5
91.6
N.A.
88.2
54.2
N.A.
85.4
55.3
76.3
75
N.A.
N.A.
N.A.
N.A.
55.3
Protein Similarity:
100
99.8
60
96
N.A.
93.7
71.9
N.A.
92.2
70.8
86.8
87.3
N.A.
N.A.
N.A.
N.A.
72.6
P-Site Identity:
100
93.3
0
80
N.A.
66.6
20
N.A.
53.3
13.3
33.3
6.6
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
93.3
0
93.3
N.A.
80
53.3
N.A.
80
20
66.6
33.3
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
47.5
44
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
64.6
61.1
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
0
6.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
6.6
33.3
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
31
16
8
16
8
0
0
8
0
0
8
0
0
0
0
% A
% Cys:
8
0
0
0
0
0
0
8
0
0
0
0
8
0
0
% C
% Asp:
8
8
0
0
16
0
0
0
0
0
0
16
0
47
0
% D
% Glu:
8
16
8
8
8
31
24
0
0
0
0
24
0
8
0
% E
% Phe:
0
0
8
8
8
0
0
0
0
8
0
0
8
0
0
% F
% Gly:
0
0
8
0
0
0
8
0
8
0
0
0
0
0
8
% G
% His:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
16
0
8
0
31
8
0
0
0
8
0
0
% I
% Lys:
8
24
0
8
16
16
8
0
0
0
0
8
0
0
0
% K
% Leu:
0
8
0
0
0
0
0
8
0
8
0
8
0
8
0
% L
% Met:
0
0
0
0
0
8
0
8
0
8
0
0
0
0
0
% M
% Asn:
8
0
8
0
0
0
0
0
0
8
0
16
0
0
0
% N
% Pro:
16
0
16
0
0
0
0
0
0
0
8
8
0
0
8
% P
% Gln:
8
8
0
0
0
0
8
0
8
0
8
0
0
0
8
% Q
% Arg:
0
16
0
0
31
0
47
0
0
39
16
0
8
8
0
% R
% Ser:
0
8
0
0
8
24
8
24
8
16
39
16
0
0
54
% S
% Thr:
0
0
0
0
8
0
0
8
0
0
16
8
8
8
0
% T
% Val:
8
0
0
47
0
0
0
8
0
16
0
0
8
24
0
% V
% Trp:
0
0
0
0
0
0
0
0
47
0
0
0
0
0
8
% W
% Tyr:
0
0
47
0
0
8
0
0
24
0
8
0
54
0
16
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _