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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ME2
All Species:
29.7
Human Site:
Y513
Identified Species:
54.44
UniProt:
P23368
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P23368
NP_002387.1
584
65444
Y513
E
L
A
Q
G
R
L
Y
P
P
L
A
N
I
Q
Chimpanzee
Pan troglodytes
XP_001154897
584
65469
Y513
E
L
A
Q
G
R
L
Y
P
P
L
A
N
I
Q
Rhesus Macaque
Macaca mulatta
XP_001099883
959
105776
Y513
E
L
A
Q
G
R
L
Y
P
P
L
A
N
I
Q
Dog
Lupus familis
XP_849530
584
65328
Y513
E
L
A
Q
G
R
L
Y
P
P
L
A
D
I
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q99KE1
589
65781
Y513
E
L
A
Q
G
R
L
Y
P
S
L
A
N
I
Q
Rat
Rattus norvegicus
P13697
572
63984
Y500
H
L
E
E
G
R
L
Y
P
P
L
N
T
I
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509137
583
65380
Y513
E
L
A
Q
G
R
L
Y
P
P
L
S
N
I
Q
Chicken
Gallus gallus
NP_989634
557
61982
R487
E
E
N
L
Q
E
G
R
L
Y
P
P
L
V
T
Frog
Xenopus laevis
NP_001082582
583
65390
Y513
E
M
G
Q
G
R
L
Y
P
A
L
S
N
I
R
Zebra Danio
Brachydanio rerio
NP_001003627
581
64913
L506
D
Q
L
T
D
E
E
L
S
Q
G
R
L
Y
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780686
581
64710
L509
K
L
V
T
Q
A
H
L
D
E
G
R
V
Y
P
Poplar Tree
Populus trichocarpa
P34105
591
65205
A518
V
H
D
D
M
L
L
A
A
A
E
A
L
A
G
Maize
Zea mays
P16243
636
69805
N537
F
V
P
G
Q
S
N
N
A
Y
I
F
P
G
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
58.5
91.6
N.A.
88.2
54.2
N.A.
85.4
55.3
76.3
75
N.A.
N.A.
N.A.
N.A.
55.3
Protein Similarity:
100
99.8
60
96
N.A.
93.7
71.9
N.A.
92.2
70.8
86.8
87.3
N.A.
N.A.
N.A.
N.A.
72.6
P-Site Identity:
100
100
100
93.3
N.A.
93.3
60
N.A.
93.3
6.6
66.6
0
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
93.3
73.3
N.A.
100
13.3
86.6
6.6
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
47.5
44
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
64.6
61.1
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
13.3
0
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
13.3
13.3
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
47
0
0
8
0
8
16
16
0
47
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
8
8
8
0
0
0
8
0
0
0
8
0
0
% D
% Glu:
62
8
8
8
0
16
8
0
0
8
8
0
0
0
0
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% F
% Gly:
0
0
8
8
62
0
8
0
0
0
16
0
0
8
8
% G
% His:
8
8
0
0
0
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
8
0
0
62
0
% I
% Lys:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
62
8
8
0
8
70
16
8
0
62
0
24
0
8
% L
% Met:
0
8
0
0
8
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
8
8
0
0
0
8
47
0
0
% N
% Pro:
0
0
8
0
0
0
0
0
62
47
8
8
8
0
16
% P
% Gln:
0
8
0
54
24
0
0
0
0
8
0
0
0
0
47
% Q
% Arg:
0
0
0
0
0
62
0
8
0
0
0
16
0
0
16
% R
% Ser:
0
0
0
0
0
8
0
0
8
8
0
16
0
0
0
% S
% Thr:
0
0
0
16
0
0
0
0
0
0
0
0
8
0
8
% T
% Val:
8
8
8
0
0
0
0
0
0
0
0
0
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
62
0
16
0
0
0
16
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _