Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ME2 All Species: 23.33
Human Site: Y535 Identified Species: 42.78
UniProt: P23368 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P23368 NP_002387.1 584 65444 Y535 I K V T E Y L Y A N K M A F R
Chimpanzee Pan troglodytes XP_001154897 584 65469 Y535 I K V T E Y L Y A N K M A F R
Rhesus Macaque Macaca mulatta XP_001099883 959 105776 E535 I K G S P E N E M A P A S C F
Dog Lupus familis XP_849530 584 65328 Y535 I K V T E Y L Y A N K M A F R
Cat Felis silvestris
Mouse Mus musculus Q99KE1 589 65781 Y535 I K L A E Y L Y A N K M A F R
Rat Rattus norvegicus P13697 572 63984 Y522 V K I V Q D A Y K E K M A T V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509137 583 65380 Y535 I K V I E Y L Y A E K M A F R
Chicken Gallus gallus NP_989634 557 61982 E509 I A V R I A E E A Y R N N T A
Frog Xenopus laevis NP_001082582 583 65390 Y535 V K V M E F V Y R N G M A F Q
Zebra Danio Brachydanio rerio NP_001003627 581 64913 K528 V S L Q M A I K V V E Y V Y S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_780686 581 64710 R531 V S V K I A V R V G E Y A Y D
Poplar Tree Populus trichocarpa P34105 591 65205 P540 A K G L I Y P P L S N I R K I
Maize Zea mays P16243 636 69805 D559 G A V R V H E D M L L A A S K
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 58.5 91.6 N.A. 88.2 54.2 N.A. 85.4 55.3 76.3 75 N.A. N.A. N.A. N.A. 55.3
Protein Similarity: 100 99.8 60 96 N.A. 93.7 71.9 N.A. 92.2 70.8 86.8 87.3 N.A. N.A. N.A. N.A. 72.6
P-Site Identity: 100 100 13.3 100 N.A. 86.6 33.3 N.A. 86.6 20 53.3 0 N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: 100 100 26.6 100 N.A. 93.3 53.3 N.A. 86.6 26.6 80 33.3 N.A. N.A. N.A. N.A. 40
Percent
Protein Identity: 47.5 44 N.A. N.A. N.A. N.A.
Protein Similarity: 64.6 61.1 N.A. N.A. N.A. N.A.
P-Site Identity: 13.3 13.3 N.A. N.A. N.A. N.A.
P-Site Similarity: 26.6 26.6 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 16 0 8 0 24 8 0 47 8 0 16 70 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % C
% Asp: 0 0 0 0 0 8 0 8 0 0 0 0 0 0 8 % D
% Glu: 0 0 0 0 47 8 16 16 0 16 16 0 0 0 0 % E
% Phe: 0 0 0 0 0 8 0 0 0 0 0 0 0 47 8 % F
% Gly: 8 0 16 0 0 0 0 0 0 8 8 0 0 0 0 % G
% His: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % H
% Ile: 54 0 8 8 24 0 8 0 0 0 0 8 0 0 8 % I
% Lys: 0 70 0 8 0 0 0 8 8 0 47 0 0 8 8 % K
% Leu: 0 0 16 8 0 0 39 0 8 8 8 0 0 0 0 % L
% Met: 0 0 0 8 8 0 0 0 16 0 0 54 0 0 0 % M
% Asn: 0 0 0 0 0 0 8 0 0 39 8 8 8 0 0 % N
% Pro: 0 0 0 0 8 0 8 8 0 0 8 0 0 0 0 % P
% Gln: 0 0 0 8 8 0 0 0 0 0 0 0 0 0 8 % Q
% Arg: 0 0 0 16 0 0 0 8 8 0 8 0 8 0 39 % R
% Ser: 0 16 0 8 0 0 0 0 0 8 0 0 8 8 8 % S
% Thr: 0 0 0 24 0 0 0 0 0 0 0 0 0 16 0 % T
% Val: 31 0 62 8 8 0 16 0 16 8 0 0 8 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 47 0 54 0 8 0 16 0 16 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _