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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RPS6KB1
All Species:
26.06
Human Site:
S375
Identified Species:
40.95
UniProt:
P23443
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P23443
NP_003152.1
525
59140
S375
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
F
Chimpanzee
Pan troglodytes
XP_523815
451
50966
K304
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
Rhesus Macaque
Macaca mulatta
XP_001109701
525
59511
S375
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
F
Dog
Lupus familis
XP_537702
525
59107
S375
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
F
Cat
Felis silvestris
Mouse
Mus musculus
Q8BSK8
525
59199
S375
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
F
Rat
Rattus norvegicus
P67999
525
59113
S375
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509850
482
54026
S332
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
F
Chicken
Gallus gallus
P18652
752
84421
Q362
P
F
K
P
A
V
G
Q
P
D
D
T
F
Y
F
Frog
Xenopus laevis
P10666
629
71268
T343
P
P
F
K
P
S
V
T
Q
P
D
D
T
Y
Y
Zebra Danio
Brachydanio rerio
Q6PFQ0
740
83378
P365
P
E
F
T
A
K
T
P
K
D
S
P
G
I
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3I5
1207
137026
V1028
P
P
P
A
L
I
P
V
E
P
E
T
T
F
R
Honey Bee
Apis mellifera
XP_395876
456
51514
R308
L
I
R
K
L
L
K
R
Q
V
A
Q
R
L
G
Nematode Worm
Caenorhab. elegans
Q21734
784
88102
S385
P
P
F
K
P
A
L
S
T
V
D
S
T
S
Y
Sea Urchin
Strong. purpuratus
XP_781234
487
53968
W338
P
F
F
R
H
V
K
W
D
D
V
L
A
R
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q39030
471
53019
V323
K
A
A
D
W
W
S
V
G
I
L
L
Y
E
M
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.9
94.2
99.8
N.A.
99.2
99.6
N.A.
90.2
31.9
36.8
32.2
N.A.
20.8
54.6
31.2
59
Protein Similarity:
100
85.9
95.6
100
N.A.
99.4
99.6
N.A.
90.8
46.6
52.7
46.6
N.A.
31.3
68
43.6
70.8
P-Site Identity:
100
6.6
100
100
N.A.
100
100
N.A.
100
40
13.3
6.6
N.A.
20
13.3
20
13.3
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
100
53.3
40
20
N.A.
40
33.3
33.3
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
36.3
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
7
14
7
0
0
0
0
7
0
7
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% C
% Asp:
0
0
0
7
0
0
7
0
7
20
60
7
0
0
0
% D
% Glu:
0
7
0
0
0
0
0
0
47
40
7
0
0
7
0
% E
% Phe:
0
54
27
0
0
0
0
0
0
0
0
0
7
7
47
% F
% Gly:
0
0
0
0
0
0
7
0
7
0
0
0
7
0
7
% G
% His:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
0
0
14
0
0
7
7
0
0
0
7
0
% I
% Lys:
7
0
54
27
0
7
14
7
7
0
7
0
7
0
7
% K
% Leu:
7
0
0
0
54
47
7
0
0
7
7
14
0
14
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% M
% Asn:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% N
% Pro:
80
20
7
47
14
0
7
7
7
14
0
7
0
0
7
% P
% Gln:
0
0
0
0
0
0
40
7
14
0
0
7
0
40
0
% Q
% Arg:
0
7
7
7
0
0
0
7
0
0
0
0
7
7
7
% R
% Ser:
0
0
0
0
0
7
7
47
0
0
7
7
40
7
0
% S
% Thr:
0
0
0
7
7
0
7
7
7
0
0
14
20
0
0
% T
% Val:
0
0
0
0
0
14
7
14
0
14
7
40
0
0
0
% V
% Trp:
0
0
0
0
7
7
0
7
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
7
14
14
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _