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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
JAK1
All Species:
19.09
Human Site:
S518
Identified Species:
46.67
UniProt:
P23458
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P23458
NP_002218.2
1154
133277
S518
G
S
D
R
S
F
P
S
L
G
D
L
M
S
H
Chimpanzee
Pan troglodytes
Q5IS37
825
92786
Q249
D
W
I
V
T
G
L
Q
S
I
N
T
H
Q
T
Rhesus Macaque
Macaca mulatta
XP_001088791
1154
133313
S518
G
S
D
R
S
F
P
S
L
G
D
L
M
S
H
Dog
Lupus familis
XP_865130
1147
132539
S511
G
S
D
R
S
F
P
S
L
G
D
L
M
S
H
Cat
Felis silvestris
Mouse
Mus musculus
P52332
1153
133349
S517
G
S
M
D
H
F
P
S
L
R
D
L
M
N
H
Rat
Rattus norvegicus
Q62689
1132
130567
S490
M
E
T
V
R
S
D
S
I
I
F
Q
F
T
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q75R65
1129
129828
D487
Q
T
E
T
V
R
S
D
S
I
I
F
Q
F
I
Frog
Xenopus laevis
NP_001086862
1142
131497
S503
G
P
D
L
E
F
D
S
L
K
D
L
M
K
H
Zebra Danio
Brachydanio rerio
O12990
1153
132463
T514
G
T
D
T
F
R
P
T
L
K
E
L
L
E
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24592
1177
135043
H510
L
S
Y
N
N
G
E
H
V
L
N
S
L
H
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
20.5
99.4
97.4
N.A.
94.6
43.7
N.A.
N.A.
43.7
75.8
62.7
N.A.
21.2
N.A.
N.A.
N.A.
Protein Similarity:
100
35.4
99.6
98.6
N.A.
96.7
62.7
N.A.
N.A.
62.7
86.2
76.5
N.A.
40
N.A.
N.A.
N.A.
P-Site Identity:
100
0
100
100
N.A.
66.6
6.6
N.A.
N.A.
0
60
40
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
13.3
100
100
N.A.
73.3
20
N.A.
N.A.
13.3
60
66.6
N.A.
33.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
50
10
0
0
20
10
0
0
50
0
0
0
0
% D
% Glu:
0
10
10
0
10
0
10
0
0
0
10
0
0
10
10
% E
% Phe:
0
0
0
0
10
50
0
0
0
0
10
10
10
10
0
% F
% Gly:
60
0
0
0
0
20
0
0
0
30
0
0
0
0
0
% G
% His:
0
0
0
0
10
0
0
10
0
0
0
0
10
10
60
% H
% Ile:
0
0
10
0
0
0
0
0
10
30
10
0
0
0
10
% I
% Lys:
0
0
0
0
0
0
0
0
0
20
0
0
0
10
10
% K
% Leu:
10
0
0
10
0
0
10
0
60
10
0
60
20
0
0
% L
% Met:
10
0
10
0
0
0
0
0
0
0
0
0
50
0
0
% M
% Asn:
0
0
0
10
10
0
0
0
0
0
20
0
0
10
0
% N
% Pro:
0
10
0
0
0
0
50
0
0
0
0
0
0
0
0
% P
% Gln:
10
0
0
0
0
0
0
10
0
0
0
10
10
10
0
% Q
% Arg:
0
0
0
30
10
20
0
0
0
10
0
0
0
0
0
% R
% Ser:
0
50
0
0
30
10
10
60
20
0
0
10
0
30
0
% S
% Thr:
0
20
10
20
10
0
0
10
0
0
0
10
0
10
10
% T
% Val:
0
0
0
20
10
0
0
0
10
0
0
0
0
0
0
% V
% Trp:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _