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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: JAK1 All Species: 22.42
Human Site: Y422 Identified Species: 54.81
UniProt: P23458 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P23458 NP_002218.2 1154 133277 Y422 L T A D A H H Y L C T D V A P
Chimpanzee Pan troglodytes Q5IS37 825 92786 C166 Q N F F N C S C D I R W M Q L
Rhesus Macaque Macaca mulatta XP_001088791 1154 133313 Y422 L T A D A H H Y L C T D V A P
Dog Lupus familis XP_865130 1147 132539 Y416 L T A D A H H Y L C T D V A P
Cat Felis silvestris
Mouse Mus musculus P52332 1153 133349 Y422 L T A D A H H Y L C T D V A P
Rat Rattus norvegicus Q62689 1132 130567 P403 I H S N C H G P I S M D F A I
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q75R65 1129 129828 P401 I Q S N C H G P I F M D F A I
Frog Xenopus laevis NP_001086862 1142 131497 Y407 L T A D A H H Y L C S D V A P
Zebra Danio Brachydanio rerio O12990 1153 132463 Y418 L T V D A H H Y L C T D V A P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24592 1177 135043 D416 L S S K W M Q D L C H S Y R T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 20.5 99.4 97.4 N.A. 94.6 43.7 N.A. N.A. 43.7 75.8 62.7 N.A. 21.2 N.A. N.A. N.A.
Protein Similarity: 100 35.4 99.6 98.6 N.A. 96.7 62.7 N.A. N.A. 62.7 86.2 76.5 N.A. 40 N.A. N.A. N.A.
P-Site Identity: 100 0 100 100 N.A. 100 20 N.A. N.A. 20 93.3 93.3 N.A. 20 N.A. N.A. N.A.
P-Site Similarity: 100 6.6 100 100 N.A. 100 46.6 N.A. N.A. 46.6 100 93.3 N.A. 33.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 50 0 60 0 0 0 0 0 0 0 0 80 0 % A
% Cys: 0 0 0 0 20 10 0 10 0 70 0 0 0 0 0 % C
% Asp: 0 0 0 60 0 0 0 10 10 0 0 80 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 10 10 0 0 0 0 0 10 0 0 20 0 0 % F
% Gly: 0 0 0 0 0 0 20 0 0 0 0 0 0 0 0 % G
% His: 0 10 0 0 0 80 60 0 0 0 10 0 0 0 0 % H
% Ile: 20 0 0 0 0 0 0 0 20 10 0 0 0 0 20 % I
% Lys: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 70 0 0 0 0 0 0 0 70 0 0 0 0 0 10 % L
% Met: 0 0 0 0 0 10 0 0 0 0 20 0 10 0 0 % M
% Asn: 0 10 0 20 10 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 20 0 0 0 0 0 0 60 % P
% Gln: 10 10 0 0 0 0 10 0 0 0 0 0 0 10 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 10 0 0 10 0 % R
% Ser: 0 10 30 0 0 0 10 0 0 10 10 10 0 0 0 % S
% Thr: 0 60 0 0 0 0 0 0 0 0 50 0 0 0 10 % T
% Val: 0 0 10 0 0 0 0 0 0 0 0 0 60 0 0 % V
% Trp: 0 0 0 0 10 0 0 0 0 0 0 10 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 60 0 0 0 0 10 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _