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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
JAK1
All Species:
22.42
Human Site:
Y422
Identified Species:
54.81
UniProt:
P23458
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P23458
NP_002218.2
1154
133277
Y422
L
T
A
D
A
H
H
Y
L
C
T
D
V
A
P
Chimpanzee
Pan troglodytes
Q5IS37
825
92786
C166
Q
N
F
F
N
C
S
C
D
I
R
W
M
Q
L
Rhesus Macaque
Macaca mulatta
XP_001088791
1154
133313
Y422
L
T
A
D
A
H
H
Y
L
C
T
D
V
A
P
Dog
Lupus familis
XP_865130
1147
132539
Y416
L
T
A
D
A
H
H
Y
L
C
T
D
V
A
P
Cat
Felis silvestris
Mouse
Mus musculus
P52332
1153
133349
Y422
L
T
A
D
A
H
H
Y
L
C
T
D
V
A
P
Rat
Rattus norvegicus
Q62689
1132
130567
P403
I
H
S
N
C
H
G
P
I
S
M
D
F
A
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q75R65
1129
129828
P401
I
Q
S
N
C
H
G
P
I
F
M
D
F
A
I
Frog
Xenopus laevis
NP_001086862
1142
131497
Y407
L
T
A
D
A
H
H
Y
L
C
S
D
V
A
P
Zebra Danio
Brachydanio rerio
O12990
1153
132463
Y418
L
T
V
D
A
H
H
Y
L
C
T
D
V
A
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24592
1177
135043
D416
L
S
S
K
W
M
Q
D
L
C
H
S
Y
R
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
20.5
99.4
97.4
N.A.
94.6
43.7
N.A.
N.A.
43.7
75.8
62.7
N.A.
21.2
N.A.
N.A.
N.A.
Protein Similarity:
100
35.4
99.6
98.6
N.A.
96.7
62.7
N.A.
N.A.
62.7
86.2
76.5
N.A.
40
N.A.
N.A.
N.A.
P-Site Identity:
100
0
100
100
N.A.
100
20
N.A.
N.A.
20
93.3
93.3
N.A.
20
N.A.
N.A.
N.A.
P-Site Similarity:
100
6.6
100
100
N.A.
100
46.6
N.A.
N.A.
46.6
100
93.3
N.A.
33.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
50
0
60
0
0
0
0
0
0
0
0
80
0
% A
% Cys:
0
0
0
0
20
10
0
10
0
70
0
0
0
0
0
% C
% Asp:
0
0
0
60
0
0
0
10
10
0
0
80
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
10
10
0
0
0
0
0
10
0
0
20
0
0
% F
% Gly:
0
0
0
0
0
0
20
0
0
0
0
0
0
0
0
% G
% His:
0
10
0
0
0
80
60
0
0
0
10
0
0
0
0
% H
% Ile:
20
0
0
0
0
0
0
0
20
10
0
0
0
0
20
% I
% Lys:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
70
0
0
0
0
0
0
0
70
0
0
0
0
0
10
% L
% Met:
0
0
0
0
0
10
0
0
0
0
20
0
10
0
0
% M
% Asn:
0
10
0
20
10
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
20
0
0
0
0
0
0
60
% P
% Gln:
10
10
0
0
0
0
10
0
0
0
0
0
0
10
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
10
0
0
10
0
% R
% Ser:
0
10
30
0
0
0
10
0
0
10
10
10
0
0
0
% S
% Thr:
0
60
0
0
0
0
0
0
0
0
50
0
0
0
10
% T
% Val:
0
0
10
0
0
0
0
0
0
0
0
0
60
0
0
% V
% Trp:
0
0
0
0
10
0
0
0
0
0
0
10
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
60
0
0
0
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _