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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MCC All Species: 31.52
Human Site: S426 Identified Species: 63.03
UniProt: P23508 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P23508 NP_001078846.1 829 93055 S426 I T L E E C K S N A E R M S M
Chimpanzee Pan troglodytes XP_517879 1064 118580 S611 I T L E E C K S N A E R M S M
Rhesus Macaque Macaca mulatta XP_001082972 1014 112870 S611 I T L E E C K S N A E R M S M
Dog Lupus familis XP_853939 829 92784 S426 I T L E E C K S N A E R M S M
Cat Felis silvestris
Mouse Mus musculus Q8R370 680 74812 C298 G S I E K L K C F N R L L L A
Rat Rattus norvegicus Q3T1I3 680 74593 C298 G N I E K L K C F N R L L L A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507243 1025 115224 S623 I T L E E C K S N A E R M S M
Chicken Gallus gallus XP_413971 825 92902 S424 I T L E E C K S N A E R M S M
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001921192 502 56563 S120 L P S S R P D S P L P P S T I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650457 715 80940 S332 P S Q D T S L S N E Q I N L V
Honey Bee Apis mellifera XP_392073 831 92638 S428 M V A E H L V S D L L E H S N
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786141 903 100683 S496 L S L E E S K S N A D R L T M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 77.6 81 97 N.A. 24.8 24.6 N.A. 75.3 95.4 N.A. 20.9 N.A. 22.3 32.4 N.A. 48.7
Protein Similarity: 100 77.9 81.5 98.3 N.A. 42.7 42.9 N.A. 78.2 97.4 N.A. 36 N.A. 43.6 54.1 N.A. 63.9
P-Site Identity: 100 100 100 100 N.A. 13.3 13.3 N.A. 100 100 N.A. 6.6 N.A. 13.3 20 N.A. 60
P-Site Similarity: 100 100 100 100 N.A. 40 33.3 N.A. 100 100 N.A. 26.6 N.A. 40 33.3 N.A. 93.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 9 0 0 0 0 0 0 59 0 0 0 0 17 % A
% Cys: 0 0 0 0 0 50 0 17 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 9 0 0 9 0 9 0 9 0 0 0 0 % D
% Glu: 0 0 0 84 59 0 0 0 0 9 50 9 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 17 0 0 0 0 0 0 % F
% Gly: 17 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 9 0 0 0 0 0 0 0 9 0 0 % H
% Ile: 50 0 17 0 0 0 0 0 0 0 0 9 0 0 9 % I
% Lys: 0 0 0 0 17 0 75 0 0 0 0 0 0 0 0 % K
% Leu: 17 0 59 0 0 25 9 0 0 17 9 17 25 25 0 % L
% Met: 9 0 0 0 0 0 0 0 0 0 0 0 50 0 59 % M
% Asn: 0 9 0 0 0 0 0 0 67 17 0 0 9 0 9 % N
% Pro: 9 9 0 0 0 9 0 0 9 0 9 9 0 0 0 % P
% Gln: 0 0 9 0 0 0 0 0 0 0 9 0 0 0 0 % Q
% Arg: 0 0 0 0 9 0 0 0 0 0 17 59 0 0 0 % R
% Ser: 0 25 9 9 0 17 0 84 0 0 0 0 9 59 0 % S
% Thr: 0 50 0 0 9 0 0 0 0 0 0 0 0 17 0 % T
% Val: 0 9 0 0 0 0 9 0 0 0 0 0 0 0 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _