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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DGKA All Species: 30.3
Human Site: S104 Identified Species: 60.61
UniProt: P23743 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P23743 NP_001336.2 735 82630 S104 N D V S C Y F S L L E G G R P
Chimpanzee Pan troglodytes XP_001169813 623 69890 W39 R V A E Y L D W D V S E L R P
Rhesus Macaque Macaca mulatta XP_001112326 735 82508 S104 N D V S C Y F S L L E G G R P
Dog Lupus familis XP_531626 735 82556 S104 S D V S C Y F S L L E G G R P
Cat Felis silvestris
Mouse Mus musculus O88673 730 82744 T105 S D V Y C Y F T L L E G G R P
Rat Rattus norvegicus P51556 727 82180 L104 V Y C Y F T L L E G G S P E D
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001235516 802 90547 S142 K D I V C Y L S L L E R G R P
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001038780 727 81728 S107 K D V S C Y F S L L E E G Q P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q01583 1211 132942 S280 K D V V C Y L S L L E A G R P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q03603 812 91362 S164 K P L I C T L S L L E A D T P
Sea Urchin Strong. purpuratus XP_001197889 1217 132437 S572 K D I V C Y L S L L E G G K P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q39017 728 79965 S103 C V C L K S M S P S Q A I V A
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 83.6 98.9 92.9 N.A. 82.3 82.7 N.A. N.A. 57.2 N.A. 62 N.A. 34.7 N.A. 46.1 35.3
Protein Similarity: 100 84.6 99.3 97 N.A. 88.9 88.9 N.A. N.A. 70 N.A. 74.5 N.A. 44.9 N.A. 62.1 45.1
P-Site Identity: 100 13.3 100 93.3 N.A. 80 0 N.A. N.A. 66.6 N.A. 80 N.A. 73.3 N.A. 40 66.6
P-Site Similarity: 100 20 100 100 N.A. 93.3 0 N.A. N.A. 73.3 N.A. 86.6 N.A. 73.3 N.A. 46.6 80
Percent
Protein Identity: N.A. N.A. N.A. 22.5 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 38.9 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 9 0 0 0 0 0 0 0 0 25 0 0 9 % A
% Cys: 9 0 17 0 75 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 67 0 0 0 0 9 0 9 0 0 0 9 0 9 % D
% Glu: 0 0 0 9 0 0 0 0 9 0 75 17 0 9 0 % E
% Phe: 0 0 0 0 9 0 42 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 9 9 42 67 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 17 9 0 0 0 0 0 0 0 0 9 0 0 % I
% Lys: 42 0 0 0 9 0 0 0 0 0 0 0 0 9 0 % K
% Leu: 0 0 9 9 0 9 42 9 75 75 0 0 9 0 0 % L
% Met: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % M
% Asn: 17 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 9 0 0 0 0 0 0 9 0 0 0 9 0 84 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 9 0 0 9 0 % Q
% Arg: 9 0 0 0 0 0 0 0 0 0 0 9 0 59 0 % R
% Ser: 17 0 0 34 0 9 0 75 0 9 9 9 0 0 0 % S
% Thr: 0 0 0 0 0 17 0 9 0 0 0 0 0 9 0 % T
% Val: 9 17 50 25 0 0 0 0 0 9 0 0 0 9 0 % V
% Trp: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % W
% Tyr: 0 9 0 17 9 67 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _