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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DGKA All Species: 13.64
Human Site: S269 Identified Species: 27.27
UniProt: P23743 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P23743 NP_001336.2 735 82630 S269 R K D I G V Q S H V W V R G G
Chimpanzee Pan troglodytes XP_001169813 623 69890 L200 L E I H D D C L Q A V G H E C
Rhesus Macaque Macaca mulatta XP_001112326 735 82508 S269 R K D I G V Q S H V W V R G G
Dog Lupus familis XP_531626 735 82556 S269 R K D I G I Q S H V W V R G G
Cat Felis silvestris
Mouse Mus musculus O88673 730 82744 S270 R K D I G V Q S H L W V R G G
Rat Rattus norvegicus P51556 727 82180 P267 R K D I G V Q P H V W V R G G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001235516 802 90547 M307 S K K N T D V M H H F W V E G
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001038780 727 81728 V272 K K E T G I A V H D W V S G N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q01583 1211 132942 D447 K K P K C G G D L L H H W V E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q03603 812 91362 H331 Q Q D K L Y H H W Q D A N A T
Sea Urchin Strong. purpuratus XP_001197889 1217 132437 M737 S K R T T N I M N H H W V E G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q39017 728 79965 G275 N E T S A D T G N S G S N C D
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 83.6 98.9 92.9 N.A. 82.3 82.7 N.A. N.A. 57.2 N.A. 62 N.A. 34.7 N.A. 46.1 35.3
Protein Similarity: 100 84.6 99.3 97 N.A. 88.9 88.9 N.A. N.A. 70 N.A. 74.5 N.A. 44.9 N.A. 62.1 45.1
P-Site Identity: 100 0 100 93.3 N.A. 93.3 93.3 N.A. N.A. 20 N.A. 40 N.A. 6.6 N.A. 6.6 13.3
P-Site Similarity: 100 6.6 100 100 N.A. 100 93.3 N.A. N.A. 26.6 N.A. 60 N.A. 20 N.A. 20 20
Percent
Protein Identity: N.A. N.A. N.A. 22.5 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 38.9 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 9 0 9 0 0 9 0 9 0 9 0 % A
% Cys: 0 0 0 0 9 0 9 0 0 0 0 0 0 9 9 % C
% Asp: 0 0 50 0 9 25 0 9 0 9 9 0 0 0 9 % D
% Glu: 0 17 9 0 0 0 0 0 0 0 0 0 0 25 9 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % F
% Gly: 0 0 0 0 50 9 9 9 0 0 9 9 0 50 59 % G
% His: 0 0 0 9 0 0 9 9 59 17 17 9 9 0 0 % H
% Ile: 0 0 9 42 0 17 9 0 0 0 0 0 0 0 0 % I
% Lys: 17 75 9 17 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 9 0 0 0 9 0 0 9 9 17 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 17 0 0 0 0 0 0 0 % M
% Asn: 9 0 0 9 0 9 0 0 17 0 0 0 17 0 9 % N
% Pro: 0 0 9 0 0 0 0 9 0 0 0 0 0 0 0 % P
% Gln: 9 9 0 0 0 0 42 0 9 9 0 0 0 0 0 % Q
% Arg: 42 0 9 0 0 0 0 0 0 0 0 0 42 0 0 % R
% Ser: 17 0 0 9 0 0 0 34 0 9 0 9 9 0 0 % S
% Thr: 0 0 9 17 17 0 9 0 0 0 0 0 0 0 9 % T
% Val: 0 0 0 0 0 34 9 9 0 34 9 50 17 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 9 0 50 17 9 0 0 % W
% Tyr: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _