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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DGKA All Species: 10
Human Site: S341 Identified Species: 20
UniProt: P23743 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P23743 NP_001336.2 735 82630 S341 I Y P S V L A S G P D R K N S
Chimpanzee Pan troglodytes XP_001169813 623 69890 S251 D D L N L S T S E A L R I D P
Rhesus Macaque Macaca mulatta XP_001112326 735 82508 S341 I Y P S V L A S G P D R K N S
Dog Lupus familis XP_531626 735 82556 S341 I Y P S V L A S G Q E R K I S
Cat Felis silvestris
Mouse Mus musculus O88673 730 82744 P337 L P P C S I Y P S V L V S G Q
Rat Rattus norvegicus P51556 727 82180 P334 L P P C S I Y P R V L V S G Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001235516 802 90547 L401 V K K E K G C L Q Q M N K L G
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001038780 727 81728 P345 Y P V V K E R P N C I K N G G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q01583 1211 132942 V517 P T A I C P A V L D R Q R S V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q03603 812 91362 P392 L P P T H I F P A F L E R K T
Sea Urchin Strong. purpuratus XP_001197889 1217 132437 E834 P K D S N A S E D V S D G G P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q39017 728 79965 K326 D S N G K L E K K P S V K R T
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 83.6 98.9 92.9 N.A. 82.3 82.7 N.A. N.A. 57.2 N.A. 62 N.A. 34.7 N.A. 46.1 35.3
Protein Similarity: 100 84.6 99.3 97 N.A. 88.9 88.9 N.A. N.A. 70 N.A. 74.5 N.A. 44.9 N.A. 62.1 45.1
P-Site Identity: 100 13.3 100 80 N.A. 6.6 6.6 N.A. N.A. 6.6 N.A. 0 N.A. 6.6 N.A. 6.6 6.6
P-Site Similarity: 100 33.3 100 86.6 N.A. 20 20 N.A. N.A. 13.3 N.A. 6.6 N.A. 26.6 N.A. 40 13.3
Percent
Protein Identity: N.A. N.A. N.A. 22.5 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 38.9 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 20 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 9 0 0 9 34 0 9 9 0 0 0 0 0 % A
% Cys: 0 0 0 17 9 0 9 0 0 9 0 0 0 0 0 % C
% Asp: 17 9 9 0 0 0 0 0 9 9 17 9 0 9 0 % D
% Glu: 0 0 0 9 0 9 9 9 9 0 9 9 0 0 0 % E
% Phe: 0 0 0 0 0 0 9 0 0 9 0 0 0 0 0 % F
% Gly: 0 0 0 9 0 9 0 0 25 0 0 0 9 34 17 % G
% His: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 25 0 0 9 0 25 0 0 0 0 9 0 9 9 0 % I
% Lys: 0 17 9 0 25 0 0 9 9 0 0 9 42 9 0 % K
% Leu: 25 0 9 0 9 34 0 9 9 0 34 0 0 9 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % M
% Asn: 0 0 9 9 9 0 0 0 9 0 0 9 9 17 0 % N
% Pro: 17 34 50 0 0 9 0 34 0 25 0 0 0 0 17 % P
% Gln: 0 0 0 0 0 0 0 0 9 17 0 9 0 0 17 % Q
% Arg: 0 0 0 0 0 0 9 0 9 0 9 34 17 9 0 % R
% Ser: 0 9 0 34 17 9 9 34 9 0 17 0 17 9 25 % S
% Thr: 0 9 0 9 0 0 9 0 0 0 0 0 0 0 17 % T
% Val: 9 0 9 9 25 0 0 9 0 25 0 25 0 0 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 25 0 0 0 0 17 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _