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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RRM1
All Species:
44.55
Human Site:
S494
Identified Species:
65.33
UniProt:
P23921
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P23921
NP_001024.1
792
90070
S494
P
V
P
E
A
C
L
S
N
K
R
H
R
P
I
Chimpanzee
Pan troglodytes
XP_001160029
792
90066
S494
P
V
P
E
A
C
L
S
N
K
R
H
R
P
I
Rhesus Macaque
Macaca mulatta
XP_001113010
792
90110
S494
P
V
P
E
A
C
L
S
N
K
R
H
R
P
I
Dog
Lupus familis
XP_534027
792
90191
S494
P
V
P
E
A
C
L
S
N
K
R
H
R
P
I
Cat
Felis silvestris
Mouse
Mus musculus
P07742
792
90201
S494
P
I
P
E
A
H
L
S
N
K
R
H
R
P
I
Rat
Rattus norvegicus
NP_001013254
792
90275
S494
P
I
P
E
A
H
L
S
N
K
R
H
R
P
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505371
792
90170
S494
P
I
P
E
A
S
T
S
N
K
R
H
R
P
I
Chicken
Gallus gallus
NP_001026008
790
90074
S494
P
V
P
E
A
E
R
S
N
R
R
H
R
P
I
Frog
Xenopus laevis
NP_001084312
797
90815
S494
P
V
P
E
A
E
Y
S
N
K
K
H
R
P
I
Zebra Danio
Brachydanio rerio
P79732
794
89798
S494
P
V
K
E
A
E
N
S
N
K
R
H
R
P
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48591
812
91959
S505
P
L
P
E
A
R
K
S
N
L
R
H
R
P
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q03604
788
88951
S500
P
V
E
E
A
R
N
S
N
M
R
H
R
P
I
Sea Urchin
Strong. purpuratus
XP_780425
797
89848
N497
V
P
E
A
K
R
S
N
F
R
H
R
P
I
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SJ20
816
91797
V494
E
V
T
A
T
V
T
V
N
L
N
K
I
I
D
Baker's Yeast
Sacchar. cerevisiae
P21672
869
97496
P493
D
R
N
Y
Y
P
V
P
E
A
R
N
S
N
M
Red Bread Mold
Neurospora crassa
Q9UW15
929
103785
N494
Y
P
V
K
E
A
H
N
S
N
M
R
H
R
P
Conservation
Percent
Protein Identity:
100
99.8
99.3
97.9
N.A.
97.3
97.4
N.A.
96.2
94
89
89.1
N.A.
73.7
N.A.
73.6
78.9
Protein Similarity:
100
100
99.6
99.3
N.A.
98.6
98.9
N.A.
98.9
97.7
95.7
94.2
N.A.
84.3
N.A.
85.8
88.8
P-Site Identity:
100
100
100
100
N.A.
86.6
86.6
N.A.
80
80
80
80
N.A.
66.6
N.A.
73.3
0
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
86.6
86.6
86.6
80
N.A.
80
N.A.
73.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
67.8
60.6
62.5
Protein Similarity:
N.A.
N.A.
N.A.
80.3
77.2
73.4
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
0
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
26.6
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
13
75
7
0
0
0
7
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
25
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% D
% Glu:
7
0
13
75
7
19
0
0
7
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% G
% His:
0
0
0
0
0
13
7
0
0
0
7
75
7
0
0
% H
% Ile:
0
19
0
0
0
0
0
0
0
0
0
0
7
13
69
% I
% Lys:
0
0
7
7
7
0
7
0
0
57
7
7
0
0
0
% K
% Leu:
0
7
0
0
0
0
38
0
0
13
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
7
7
0
0
0
7
% M
% Asn:
0
0
7
0
0
0
13
13
82
7
7
7
0
7
0
% N
% Pro:
75
13
63
0
0
7
0
7
0
0
0
0
7
75
7
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
7
0
0
0
19
7
0
0
13
75
13
75
7
0
% R
% Ser:
0
0
0
0
0
7
7
75
7
0
0
0
7
0
0
% S
% Thr:
0
0
7
0
7
0
13
0
0
0
0
0
0
0
0
% T
% Val:
7
57
7
0
0
7
7
7
0
0
0
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
7
7
0
7
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _