Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RRM1 All Species: 57.27
Human Site: S705 Identified Species: 84
UniProt: P23921 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P23921 NP_001024.1 792 90070 S705 R G A F I D Q S Q S L N I H I
Chimpanzee Pan troglodytes XP_001160029 792 90066 S705 R G A F I D Q S Q S L N I H I
Rhesus Macaque Macaca mulatta XP_001113010 792 90110 S705 R G A F I D Q S Q S L N I H I
Dog Lupus familis XP_534027 792 90191 S705 R G A F I D Q S Q S L N I H I
Cat Felis silvestris
Mouse Mus musculus P07742 792 90201 S705 R G A F I D Q S Q S L N I H I
Rat Rattus norvegicus NP_001013254 792 90275 S705 R G A F I D Q S Q S L N I H I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505371 792 90170 S705 R G A F I D Q S Q S L N I H I
Chicken Gallus gallus NP_001026008 790 90074 D703 A D R G A F I D Q S Q S L N I
Frog Xenopus laevis NP_001084312 797 90815 S705 R G A F I D Q S Q S L N I H V
Zebra Danio Brachydanio rerio P79732 794 89798 S705 R G A Y I D Q S Q S L N I H I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P48591 812 91959 S716 R G A F I D Q S Q S F N I H V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q03604 788 88951 A702 K D I I E M A A D R G A Y I D
Sea Urchin Strong. purpuratus XP_780425 797 89848 S707 R G A Y I D Q S Q S L N I H I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SJ20 816 91797 S724 R G C Y I D Q S Q S L N I H M
Baker's Yeast Sacchar. cerevisiae P21672 869 97496 S709 R A I Y I D Q S H S L N L F L
Red Bread Mold Neurospora crassa Q9UW15 929 103785 S706 R G A F I D Q S Q S L N I H M
Conservation
Percent
Protein Identity: 100 99.8 99.3 97.9 N.A. 97.3 97.4 N.A. 96.2 94 89 89.1 N.A. 73.7 N.A. 73.6 78.9
Protein Similarity: 100 100 99.6 99.3 N.A. 98.6 98.9 N.A. 98.9 97.7 95.7 94.2 N.A. 84.3 N.A. 85.8 88.8
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 100 20 93.3 93.3 N.A. 86.6 N.A. 0 93.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 40 100 100 N.A. 93.3 N.A. 13.3 100
Percent
Protein Identity: N.A. N.A. N.A. 67.8 60.6 62.5
Protein Similarity: N.A. N.A. N.A. 80.3 77.2 73.4
P-Site Identity: N.A. N.A. N.A. 80 53.3 93.3
P-Site Similarity: N.A. N.A. N.A. 93.3 73.3 100
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 7 75 0 7 0 7 7 0 0 0 7 0 0 0 % A
% Cys: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 13 0 0 0 88 0 7 7 0 0 0 0 0 7 % D
% Glu: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 63 0 7 0 0 0 0 7 0 0 7 0 % F
% Gly: 0 82 0 7 0 0 0 0 0 0 7 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 7 0 0 0 0 82 0 % H
% Ile: 0 0 13 7 88 0 7 0 0 0 0 0 82 7 63 % I
% Lys: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 82 0 13 0 7 % L
% Met: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 13 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 88 0 7 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 88 0 88 0 7 0 0 0 0 % Q
% Arg: 88 0 7 0 0 0 0 0 0 7 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 88 0 94 0 7 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 13 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 25 0 0 0 0 0 0 0 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _