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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RRM1 All Species: 57.58
Human Site: Y553 Identified Species: 84.44
UniProt: P23921 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P23921 NP_001024.1 792 90070 Y553 L A K E Q G P Y E T Y E G S P
Chimpanzee Pan troglodytes XP_001160029 792 90066 Y553 L A K E Q G P Y E T Y E G S P
Rhesus Macaque Macaca mulatta XP_001113010 792 90110 Y553 L A K E Q G P Y E T Y E G S P
Dog Lupus familis XP_534027 792 90191 Y553 L A K E H G P Y E T Y E G S P
Cat Felis silvestris
Mouse Mus musculus P07742 792 90201 Y553 L A K E Y G P Y E T Y E G S P
Rat Rattus norvegicus NP_001013254 792 90275 Y553 L A K E Y G P Y E T Y E G S P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505371 792 90170 Y553 L A K D H G P Y E T Y Q G S P
Chicken Gallus gallus NP_001026008 790 90074 Y553 L A E Q Q G P Y E T Y E G S P
Frog Xenopus laevis NP_001084312 797 90815 Y553 L A K E L G P Y E T Y E G C P
Zebra Danio Brachydanio rerio P79732 794 89798 Y553 L A A E Y G P Y Q T Y A G C P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P48591 812 91959 Y564 L A Q T E G P Y E T Y E G S P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q03604 788 88951 E554 E A S C E L A E L N G P Y S T
Sea Urchin Strong. purpuratus XP_780425 797 89848 Y555 I A A K L G P Y E T Y K G S P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SJ20 816 91797 Y572 L A A R L G P Y E T Y A G S P
Baker's Yeast Sacchar. cerevisiae P21672 869 97496 Y557 L A Q K E G K Y S T F E G S P
Red Bread Mold Neurospora crassa Q9UW15 929 103785 Y554 L A K E Q G P Y A T Y E G S P
Conservation
Percent
Protein Identity: 100 99.8 99.3 97.9 N.A. 97.3 97.4 N.A. 96.2 94 89 89.1 N.A. 73.7 N.A. 73.6 78.9
Protein Similarity: 100 100 99.6 99.3 N.A. 98.6 98.9 N.A. 98.9 97.7 95.7 94.2 N.A. 84.3 N.A. 85.8 88.8
P-Site Identity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. 80 86.6 86.6 66.6 N.A. 80 N.A. 13.3 66.6
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. 93.3 100 86.6 73.3 N.A. 93.3 N.A. 20 86.6
Percent
Protein Identity: N.A. N.A. N.A. 67.8 60.6 62.5
Protein Similarity: N.A. N.A. N.A. 80.3 77.2 73.4
P-Site Identity: N.A. N.A. N.A. 73.3 60 93.3
P-Site Similarity: N.A. N.A. N.A. 73.3 86.6 93.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 100 19 0 0 0 7 0 7 0 0 13 0 0 0 % A
% Cys: 0 0 0 7 0 0 0 0 0 0 0 0 0 13 0 % C
% Asp: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 7 0 7 57 19 0 0 7 75 0 0 69 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % F
% Gly: 0 0 0 0 0 94 0 0 0 0 7 0 94 0 0 % G
% His: 0 0 0 0 13 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 57 13 0 0 7 0 0 0 0 7 0 0 0 % K
% Leu: 88 0 0 0 19 7 0 0 7 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 88 0 0 0 0 7 0 0 94 % P
% Gln: 0 0 13 7 32 0 0 0 7 0 0 7 0 0 0 % Q
% Arg: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 7 0 0 0 0 0 7 0 0 0 0 88 0 % S
% Thr: 0 0 0 7 0 0 0 0 0 94 0 0 0 0 7 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 19 0 0 94 0 0 88 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _