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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RRM1
All Species:
56.97
Human Site:
Y620
Identified Species:
83.56
UniProt:
P23921
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P23921
NP_001024.1
792
90070
Y620
N
N
E
S
I
E
P
Y
T
S
N
I
Y
T
R
Chimpanzee
Pan troglodytes
XP_001160029
792
90066
Y620
N
N
E
S
I
E
P
Y
T
S
N
I
Y
T
R
Rhesus Macaque
Macaca mulatta
XP_001113010
792
90110
Y620
N
N
E
S
I
E
P
Y
T
S
N
I
Y
T
R
Dog
Lupus familis
XP_534027
792
90191
Y620
N
N
E
S
I
E
P
Y
T
S
N
I
Y
T
R
Cat
Felis silvestris
Mouse
Mus musculus
P07742
792
90201
Y620
N
N
E
S
I
E
P
Y
T
S
N
I
Y
T
R
Rat
Rattus norvegicus
NP_001013254
792
90275
Y620
N
N
E
S
I
E
P
Y
T
S
N
I
Y
T
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505371
792
90170
Y620
N
N
E
S
I
E
P
Y
T
S
N
I
Y
T
R
Chicken
Gallus gallus
NP_001026008
790
90074
Y620
N
N
E
S
I
E
P
Y
T
S
N
I
Y
T
R
Frog
Xenopus laevis
NP_001084312
797
90815
Y620
N
N
E
S
I
E
P
Y
T
S
N
I
Y
T
R
Zebra Danio
Brachydanio rerio
P79732
794
89798
Y620
N
N
E
S
I
E
P
Y
T
S
N
I
Y
H
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48591
812
91959
Y631
N
N
E
S
F
E
P
Y
T
T
N
I
Y
T
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q03604
788
88951
E621
A
Q
I
L
G
N
N
E
S
I
E
P
Y
T
S
Sea Urchin
Strong. purpuratus
XP_780425
797
89848
Y622
N
N
E
A
I
E
P
Y
T
S
N
I
Y
T
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SJ20
816
91797
Y639
N
N
E
C
F
E
P
Y
T
S
N
I
Y
S
R
Baker's Yeast
Sacchar. cerevisiae
P21672
869
97496
V624
Y
N
E
C
F
E
P
V
T
S
N
M
Y
S
R
Red Bread Mold
Neurospora crassa
Q9UW15
929
103785
Y621
N
N
E
C
F
E
P
Y
T
S
N
I
Y
Q
R
Conservation
Percent
Protein Identity:
100
99.8
99.3
97.9
N.A.
97.3
97.4
N.A.
96.2
94
89
89.1
N.A.
73.7
N.A.
73.6
78.9
Protein Similarity:
100
100
99.6
99.3
N.A.
98.6
98.9
N.A.
98.9
97.7
95.7
94.2
N.A.
84.3
N.A.
85.8
88.8
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
93.3
N.A.
86.6
N.A.
13.3
93.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
93.3
N.A.
93.3
N.A.
20
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
67.8
60.6
62.5
Protein Similarity:
N.A.
N.A.
N.A.
80.3
77.2
73.4
P-Site Identity:
N.A.
N.A.
N.A.
80
60
80
P-Site Similarity:
N.A.
N.A.
N.A.
86.6
73.3
80
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
19
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
94
0
0
94
0
7
0
0
7
0
0
0
0
% E
% Phe:
0
0
0
0
25
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% H
% Ile:
0
0
7
0
69
0
0
0
0
7
0
88
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% M
% Asn:
88
94
0
0
0
7
7
0
0
0
94
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
94
0
0
0
0
7
0
0
0
% P
% Gln:
0
7
0
0
0
0
0
0
0
0
0
0
0
7
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
94
% R
% Ser:
0
0
0
69
0
0
0
0
7
88
0
0
0
13
7
% S
% Thr:
0
0
0
0
0
0
0
0
94
7
0
0
0
75
0
% T
% Val:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
0
0
88
0
0
0
0
100
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _