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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IGFBP6
All Species:
4.85
Human Site:
S148
Identified Species:
13.33
UniProt:
P24592
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P24592
NP_002169.1
240
25322
S148
P
G
T
S
T
T
P
S
Q
P
N
S
A
G
V
Chimpanzee
Pan troglodytes
XP_509089
241
25403
S149
P
G
T
S
T
T
P
S
Q
P
N
S
A
G
V
Rhesus Macaque
Macaca mulatta
XP_001112730
110
11146
P21
A
L
L
L
A
A
S
P
G
G
A
L
A
R
C
Dog
Lupus familis
XP_849343
240
25554
G148
G
A
S
T
T
T
S
G
R
P
N
P
G
G
V
Cat
Felis silvestris
Mouse
Mus musculus
P47880
238
25384
A145
K
N
P
R
T
S
A
A
P
I
R
P
N
P
V
Rat
Rattus norvegicus
P35572
226
24175
A133
K
N
P
R
T
S
A
A
P
I
R
P
S
P
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P49705
311
33520
R204
H
E
D
S
K
K
S
R
M
P
T
G
R
T
P
Frog
Xenopus laevis
Q90WV8
265
29976
S170
V
S
V
E
K
V
Q
S
P
S
T
P
E
H
S
Zebra Danio
Brachydanio rerio
Q9PTH3
276
30746
A172
H
K
V
E
D
P
K
A
P
H
A
K
Q
S
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
44.1
84.1
N.A.
69.5
66.2
N.A.
N.A.
30.2
35.4
30.4
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
45.4
87
N.A.
78.3
73.3
N.A.
N.A.
40.1
52
43.4
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
6.6
40
N.A.
13.3
13.3
N.A.
N.A.
13.3
6.6
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
6.6
60
N.A.
26.6
33.3
N.A.
N.A.
13.3
6.6
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
12
0
0
12
12
23
34
0
0
23
0
34
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
12
% C
% Asp:
0
0
12
0
12
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
12
0
23
0
0
0
0
0
0
0
0
12
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
12
23
0
0
0
0
0
12
12
12
0
12
12
34
0
% G
% His:
23
0
0
0
0
0
0
0
0
12
0
0
0
12
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
23
0
0
0
0
0
% I
% Lys:
23
12
0
0
23
12
12
0
0
0
0
12
0
0
0
% K
% Leu:
0
12
12
12
0
0
0
0
0
0
0
12
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
12
0
0
0
0
0
0
% M
% Asn:
0
23
0
0
0
0
0
0
0
0
34
0
12
0
0
% N
% Pro:
23
0
23
0
0
12
23
12
45
45
0
45
0
23
12
% P
% Gln:
0
0
0
0
0
0
12
0
23
0
0
0
12
0
12
% Q
% Arg:
0
0
0
23
0
0
0
12
12
0
23
0
12
12
0
% R
% Ser:
0
12
12
34
0
23
34
34
0
12
0
23
12
12
12
% S
% Thr:
0
0
23
12
56
34
0
0
0
0
23
0
0
12
0
% T
% Val:
12
0
23
0
0
12
0
0
0
0
0
0
0
0
56
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _