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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IGFBP5
All Species:
16.67
Human Site:
S105
Identified Species:
36.67
UniProt:
P24593
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P24593
NP_000590.1
272
30570
S105
G
V
C
L
N
E
K
S
Y
R
E
Q
V
K
I
Chimpanzee
Pan troglodytes
XP_511475
258
27929
L90
P
R
G
V
E
K
P
L
H
T
L
M
H
G
Q
Rhesus Macaque
Macaca mulatta
XP_001087426
331
37178
S105
G
V
C
L
N
E
K
S
Y
R
E
Q
V
K
I
Dog
Lupus familis
XP_852885
271
30322
S104
G
V
C
L
N
E
K
S
Y
R
E
Q
A
K
I
Cat
Felis silvestris
Mouse
Mus musculus
Q07079
271
30353
S104
G
V
C
L
N
E
K
S
Y
G
E
Q
T
K
I
Rat
Rattus norvegicus
P24594
271
30279
S104
G
V
C
L
N
E
K
S
Y
G
E
Q
T
K
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520993
182
18311
P17
L
P
G
L
P
G
L
P
G
L
G
L
L
V
G
Chicken
Gallus gallus
P49705
311
33520
P106
P
D
P
G
A
E
L
P
P
Q
A
L
V
Q
G
Frog
Xenopus laevis
Q90WV8
265
29976
G99
H
A
L
L
H
G
R
G
V
C
L
N
L
K
N
Zebra Danio
Brachydanio rerio
B3F211
265
29421
E87
A
N
S
E
L
P
L
E
Q
L
I
Q
G
L
G
Tiger Blowfish
Takifugu rubipres
NP_001139534
261
28881
V95
R
C
Y
P
P
R
G
V
E
R
P
L
H
S
L
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
41.5
81.2
97.7
N.A.
95.2
94.4
N.A.
43
31.1
66.5
33
36.7
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
55.5
82.1
98.5
N.A.
96.6
96.3
N.A.
47
44.6
78.6
45.5
53.6
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
0
100
93.3
N.A.
86.6
86.6
N.A.
6.6
13.3
13.3
6.6
6.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
20
100
93.3
N.A.
86.6
86.6
N.A.
13.3
26.6
33.3
6.6
13.3
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
0
0
10
0
0
0
0
0
10
0
10
0
0
% A
% Cys:
0
10
46
0
0
0
0
0
0
10
0
0
0
0
0
% C
% Asp:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
10
10
55
0
10
10
0
46
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
46
0
19
10
0
19
10
10
10
19
10
0
10
10
28
% G
% His:
10
0
0
0
10
0
0
0
10
0
0
0
19
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
46
% I
% Lys:
0
0
0
0
0
10
46
0
0
0
0
0
0
55
0
% K
% Leu:
10
0
10
64
10
0
28
10
0
19
19
28
19
10
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% M
% Asn:
0
10
0
0
46
0
0
0
0
0
0
10
0
0
10
% N
% Pro:
19
10
10
10
19
10
10
19
10
0
10
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
10
10
0
55
0
10
10
% Q
% Arg:
10
10
0
0
0
10
10
0
0
37
0
0
0
0
0
% R
% Ser:
0
0
10
0
0
0
0
46
0
0
0
0
0
10
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
10
0
0
19
0
0
% T
% Val:
0
46
0
10
0
0
0
10
10
0
0
0
28
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
10
0
0
0
0
0
46
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _