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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACAT1
All Species:
28.18
Human Site:
T168
Identified Species:
47.69
UniProt:
P24752
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P24752
NP_000010.1
427
45200
T168
Y
V
M
N
R
G
S
T
P
Y
G
G
V
K
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001103928
427
45080
T168
Y
V
M
N
R
G
S
T
P
Y
G
G
V
K
L
Dog
Lupus familis
XP_546539
433
45733
T174
Y
V
M
S
R
G
A
T
P
Y
G
G
V
K
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8QZT1
424
44798
T165
Y
V
M
S
R
G
A
T
P
Y
G
G
V
K
L
Rat
Rattus norvegicus
P17764
424
44676
T165
Y
V
M
S
R
G
A
T
P
Y
G
G
V
K
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508601
416
43920
Y159
M
S
R
G
S
T
P
Y
G
G
V
K
L
E
D
Chicken
Gallus gallus
XP_417162
421
44071
T162
Y
T
M
S
R
G
S
T
P
Y
G
G
V
N
L
Frog
Xenopus laevis
Q6GN02
420
44054
T161
Y
C
M
S
R
G
A
T
P
Y
G
G
V
K
L
Zebra Danio
Brachydanio rerio
Q6AZA0
420
44324
P161
Y
I
M
A
R
E
A
P
P
Y
G
G
V
K
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572414
410
43452
D160
Y
G
G
V
N
L
T
D
G
I
V
F
D
G
L
Honey Bee
Apis mellifera
XP_001121974
405
43669
T163
G
I
V
F
D
G
L
T
D
V
Y
N
K
F
H
Nematode Worm
Caenorhab. elegans
NP_495455
407
42424
D168
I
V
K
D
G
L
T
D
A
Y
D
K
V
H
M
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FIK7
415
43273
V162
M
K
D
G
L
W
D
V
Y
N
D
F
G
M
G
Baker's Yeast
Sacchar. cerevisiae
P41338
398
41710
V162
Y
D
G
L
A
M
G
V
H
A
E
K
C
A
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
85.2
N.A.
84.3
84.5
N.A.
77.5
77.2
74.7
77.2
N.A.
62.7
63
51.9
N.A.
Protein Similarity:
100
N.A.
99
91.4
N.A.
91.8
92
N.A.
86.1
85.9
86.4
86.6
N.A.
76.5
76.3
68.6
N.A.
P-Site Identity:
100
N.A.
100
86.6
N.A.
86.6
86.6
N.A.
0
80
80
60
N.A.
13.3
13.3
20
N.A.
P-Site Similarity:
100
N.A.
100
100
N.A.
100
100
N.A.
13.3
86.6
93.3
80
N.A.
20
26.6
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
48.9
42.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
66
61.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
8
0
36
0
8
8
0
0
0
8
0
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
0
0
8
0
0
% C
% Asp:
0
8
8
8
8
0
8
15
8
0
15
0
8
0
8
% D
% Glu:
0
0
0
0
0
8
0
0
0
0
8
0
0
8
0
% E
% Phe:
0
0
0
8
0
0
0
0
0
0
0
15
0
8
0
% F
% Gly:
8
8
15
15
8
58
8
0
15
8
58
58
8
8
8
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
0
8
8
% H
% Ile:
8
15
0
0
0
0
0
0
0
8
0
0
0
0
0
% I
% Lys:
0
8
8
0
0
0
0
0
0
0
0
22
8
50
0
% K
% Leu:
0
0
0
8
8
15
8
0
0
0
0
0
8
0
58
% L
% Met:
15
0
58
0
0
8
0
0
0
0
0
0
0
8
15
% M
% Asn:
0
0
0
15
8
0
0
0
0
8
0
8
0
8
0
% N
% Pro:
0
0
0
0
0
0
8
8
58
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
8
0
58
0
0
0
0
0
0
0
0
0
8
% R
% Ser:
0
8
0
36
8
0
22
0
0
0
0
0
0
0
0
% S
% Thr:
0
8
0
0
0
8
15
58
0
0
0
0
0
0
0
% T
% Val:
0
43
8
8
0
0
0
15
0
8
15
0
65
0
0
% V
% Trp:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% W
% Tyr:
72
0
0
0
0
0
0
8
8
65
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _