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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACAT1
All Species:
31.52
Human Site:
Y188
Identified Species:
53.33
UniProt:
P24752
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P24752
NP_000010.1
427
45200
Y188
K
D
G
L
T
D
V
Y
N
K
I
H
M
G
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001103928
427
45080
Y188
K
D
G
L
T
D
V
Y
N
K
I
H
M
G
S
Dog
Lupus familis
XP_546539
433
45733
Y194
K
D
G
L
T
D
V
Y
N
K
I
H
M
G
N
Cat
Felis silvestris
Mouse
Mus musculus
Q8QZT1
424
44798
Y185
K
D
G
L
T
D
V
Y
N
K
I
H
M
G
N
Rat
Rattus norvegicus
P17764
424
44676
Y185
K
D
G
L
T
D
V
Y
N
K
I
H
M
G
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508601
416
43920
K179
G
L
T
D
V
Y
N
K
I
H
M
G
N
C
A
Chicken
Gallus gallus
XP_417162
421
44071
Y182
K
D
G
L
T
D
V
Y
N
H
I
H
M
G
N
Frog
Xenopus laevis
Q6GN02
420
44054
Y181
K
D
G
L
T
D
V
Y
N
K
F
H
M
G
N
Zebra Danio
Brachydanio rerio
Q6AZA0
420
44324
Y181
K
D
G
L
T
D
V
Y
N
K
F
H
M
G
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572414
410
43452
A180
K
F
H
M
G
N
C
A
E
N
T
A
K
K
L
Honey Bee
Apis mellifera
XP_001121974
405
43669
N183
E
N
V
A
K
K
L
N
I
T
R
D
E
Q
D
Nematode Worm
Caenorhab. elegans
NP_495455
407
42424
I188
K
T
S
K
E
M
G
I
T
R
K
D
Q
D
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FIK7
415
43273
T182
C
A
D
Q
Y
R
I
T
R
E
E
Q
D
A
Y
Baker's Yeast
Sacchar. cerevisiae
P41338
398
41710
A182
R
E
Q
Q
D
N
F
A
I
E
S
Y
Q
K
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
85.2
N.A.
84.3
84.5
N.A.
77.5
77.2
74.7
77.2
N.A.
62.7
63
51.9
N.A.
Protein Similarity:
100
N.A.
99
91.4
N.A.
91.8
92
N.A.
86.1
85.9
86.4
86.6
N.A.
76.5
76.3
68.6
N.A.
P-Site Identity:
100
N.A.
100
93.3
N.A.
93.3
93.3
N.A.
0
86.6
86.6
86.6
N.A.
6.6
0
6.6
N.A.
P-Site Similarity:
100
N.A.
100
100
N.A.
100
100
N.A.
13.3
93.3
93.3
93.3
N.A.
20
20
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
48.9
42.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
66
61.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
8
0
0
0
15
0
0
0
8
0
8
8
% A
% Cys:
8
0
0
0
0
0
8
0
0
0
0
0
0
8
0
% C
% Asp:
0
58
8
8
8
58
0
0
0
0
0
15
8
8
8
% D
% Glu:
8
8
0
0
8
0
0
0
8
15
8
0
8
0
8
% E
% Phe:
0
8
0
0
0
0
8
0
0
0
15
0
0
0
0
% F
% Gly:
8
0
58
0
8
0
8
0
0
0
0
8
0
58
0
% G
% His:
0
0
8
0
0
0
0
0
0
15
0
58
0
0
0
% H
% Ile:
0
0
0
0
0
0
8
8
22
0
43
0
0
0
0
% I
% Lys:
72
0
0
8
8
8
0
8
0
50
8
0
8
15
0
% K
% Leu:
0
8
0
58
0
0
8
0
0
0
0
0
0
0
8
% L
% Met:
0
0
0
8
0
8
0
0
0
0
8
0
58
0
0
% M
% Asn:
0
8
0
0
0
15
8
8
58
8
0
0
8
0
43
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
8
15
0
0
0
0
0
0
0
8
15
8
0
% Q
% Arg:
8
0
0
0
0
8
0
0
8
8
8
0
0
0
0
% R
% Ser:
0
0
8
0
0
0
0
0
0
0
8
0
0
0
22
% S
% Thr:
0
8
8
0
58
0
0
8
8
8
8
0
0
0
0
% T
% Val:
0
0
8
0
8
0
58
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
8
0
58
0
0
0
8
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _