KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACAT1
All Species:
19.39
Human Site:
Y214
Identified Species:
32.82
UniProt:
P24752
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P24752
NP_000010.1
427
45200
Y214
A
R
N
E
Q
D
A
Y
A
I
N
S
Y
T
R
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001103928
427
45080
Y214
A
R
D
E
Q
D
A
Y
A
I
N
S
Y
T
R
Dog
Lupus familis
XP_546539
433
45733
Y220
T
R
E
E
Q
D
T
Y
A
L
S
S
Y
T
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8QZT1
424
44798
Y211
S
R
Q
E
Q
D
T
Y
A
L
S
S
Y
T
R
Rat
Rattus norvegicus
P17764
424
44676
Y211
S
R
E
E
Q
D
K
Y
A
I
G
S
Y
T
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508601
416
43920
I205
E
E
Q
D
A
Y
A
I
S
S
Y
T
K
S
K
Chicken
Gallus gallus
XP_417162
421
44071
Y208
S
R
E
E
Q
D
T
Y
A
I
G
S
Y
T
K
Frog
Xenopus laevis
Q6GN02
420
44054
F207
S
R
E
E
Q
D
G
F
A
I
T
S
Y
T
R
Zebra Danio
Brachydanio rerio
Q6AZA0
420
44324
F207
S
R
E
E
Q
D
A
F
A
I
K
S
Y
T
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572414
410
43452
A206
I
E
S
Y
K
R
S
A
A
A
W
A
N
K
V
Honey Bee
Apis mellifera
XP_001121974
405
43669
F209
A
A
Y
V
N
K
I
F
Q
N
E
L
V
S
V
Nematode Worm
Caenorhab. elegans
NP_495455
407
42424
G214
A
W
E
N
G
N
I
G
P
E
V
V
P
V
N
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FIK7
415
43273
W208
Q
N
T
Q
L
F
A
W
E
I
V
P
V
E
V
Baker's Yeast
Sacchar. cerevisiae
P41338
398
41710
K208
E
I
V
P
V
T
I
K
G
F
R
G
K
P
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
85.2
N.A.
84.3
84.5
N.A.
77.5
77.2
74.7
77.2
N.A.
62.7
63
51.9
N.A.
Protein Similarity:
100
N.A.
99
91.4
N.A.
91.8
92
N.A.
86.1
85.9
86.4
86.6
N.A.
76.5
76.3
68.6
N.A.
P-Site Identity:
100
N.A.
93.3
66.6
N.A.
66.6
73.3
N.A.
6.6
66.6
66.6
66.6
N.A.
6.6
6.6
6.6
N.A.
P-Site Similarity:
100
N.A.
100
80
N.A.
86.6
80
N.A.
40
80
80
80
N.A.
33.3
20
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
48.9
42.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
66
61.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
29
8
0
0
8
0
36
8
65
8
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
8
0
58
0
0
0
0
0
0
0
0
8
% D
% Glu:
15
15
43
58
0
0
0
0
8
8
8
0
0
8
0
% E
% Phe:
0
0
0
0
0
8
0
22
0
8
0
0
0
0
0
% F
% Gly:
0
0
0
0
8
0
8
8
8
0
15
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
8
0
0
0
0
22
8
0
50
0
0
0
0
0
% I
% Lys:
0
0
0
0
8
8
8
8
0
0
8
0
15
8
15
% K
% Leu:
0
0
0
0
8
0
0
0
0
15
0
8
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
8
8
8
8
0
0
0
8
15
0
8
0
8
% N
% Pro:
0
0
0
8
0
0
0
0
8
0
0
8
8
8
0
% P
% Gln:
8
0
15
8
58
0
0
0
8
0
0
0
0
0
0
% Q
% Arg:
0
58
0
0
0
8
0
0
0
0
8
0
0
0
43
% R
% Ser:
36
0
8
0
0
0
8
0
8
8
15
58
0
15
0
% S
% Thr:
8
0
8
0
0
8
22
0
0
0
8
8
0
58
0
% T
% Val:
0
0
8
8
8
0
0
0
0
0
15
8
15
8
22
% V
% Trp:
0
8
0
0
0
0
0
8
0
0
8
0
0
0
0
% W
% Tyr:
0
0
8
8
0
8
0
43
0
0
8
0
58
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _