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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACAT1
All Species:
13.33
Human Site:
Y33
Identified Species:
22.56
UniProt:
P24752
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P24752
NP_000010.1
427
45200
Y33
I
R
Y
V
E
R
S
Y
V
S
K
P
T
L
K
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001103928
427
45080
Y33
I
R
Y
V
E
R
S
Y
V
S
K
P
T
L
K
Dog
Lupus familis
XP_546539
433
45733
Y39
V
R
Y
V
E
R
S
Y
V
S
K
P
T
L
N
Cat
Felis silvestris
Mouse
Mus musculus
Q8QZT1
424
44798
P34
E
R
S
Y
A
S
K
P
T
L
N
E
V
V
I
Rat
Rattus norvegicus
P17764
424
44676
P34
G
R
S
Y
A
S
K
P
T
L
N
D
V
V
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508601
416
43920
T31
R
H
Y
A
S
Q
S
T
L
N
E
V
V
I
V
Chicken
Gallus gallus
XP_417162
421
44071
R31
S
R
G
Y
A
S
Q
R
T
L
N
E
V
V
I
Frog
Xenopus laevis
Q6GN02
420
44054
T31
R
S
F
A
S
P
R
T
L
N
E
V
V
I
A
Zebra Danio
Brachydanio rerio
Q6AZA0
420
44324
L32
S
Y
S
T
R
P
S
L
N
E
V
V
I
V
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572414
410
43452
A31
E
V
V
V
V
S
A
A
R
T
P
I
G
S
F
Honey Bee
Apis mellifera
XP_001121974
405
43669
F33
T
R
T
P
M
G
S
F
L
G
E
L
S
D
L
Nematode Worm
Caenorhab. elegans
NP_495455
407
42424
F37
A
R
T
P
I
G
S
F
R
S
S
L
S
S
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FIK7
415
43273
S31
P
I
G
D
F
L
G
S
L
S
S
L
T
A
T
Baker's Yeast
Sacchar. cerevisiae
P41338
398
41710
V33
T
A
V
E
L
G
A
V
A
L
K
G
A
L
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
85.2
N.A.
84.3
84.5
N.A.
77.5
77.2
74.7
77.2
N.A.
62.7
63
51.9
N.A.
Protein Similarity:
100
N.A.
99
91.4
N.A.
91.8
92
N.A.
86.1
85.9
86.4
86.6
N.A.
76.5
76.3
68.6
N.A.
P-Site Identity:
100
N.A.
100
86.6
N.A.
6.6
6.6
N.A.
13.3
6.6
0
6.6
N.A.
6.6
13.3
20
N.A.
P-Site Similarity:
100
N.A.
100
93.3
N.A.
13.3
13.3
N.A.
46.6
13.3
33.3
13.3
N.A.
20
40
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
48.9
42.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
66
61.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
15
22
0
15
8
8
0
0
0
8
8
15
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
0
0
0
0
0
8
0
8
0
% D
% Glu:
15
0
0
8
22
0
0
0
0
8
22
15
0
0
0
% E
% Phe:
0
0
8
0
8
0
0
15
0
0
0
0
0
0
8
% F
% Gly:
8
0
15
0
0
22
8
0
0
8
0
8
8
0
0
% G
% His:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
15
8
0
0
8
0
0
0
0
0
0
8
8
15
22
% I
% Lys:
0
0
0
0
0
0
15
0
0
0
29
0
0
0
15
% K
% Leu:
0
0
0
0
8
8
0
8
29
29
0
22
0
29
8
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
8
15
22
0
0
0
8
% N
% Pro:
8
0
0
15
0
15
0
15
0
0
8
22
0
0
0
% P
% Gln:
0
0
0
0
0
8
8
0
0
0
0
0
0
0
0
% Q
% Arg:
15
58
0
0
8
22
8
8
15
0
0
0
0
0
0
% R
% Ser:
15
8
22
0
15
29
50
8
0
36
15
0
15
15
8
% S
% Thr:
15
0
15
8
0
0
0
15
22
8
0
0
29
0
8
% T
% Val:
8
8
15
29
8
0
0
8
22
0
8
22
36
29
15
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
29
22
0
0
0
22
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _