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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDK2 All Species: 21.82
Human Site: S264 Identified Species: 30
UniProt: P24941 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P24941 NP_001789.2 298 33930 S264 E D G R S L L S Q M L H Y D P
Chimpanzee Pan troglodytes XP_523720 325 36841 M284 P E G R D L L M Q L L Q Y D P
Rhesus Macaque Macaca mulatta XP_001113345 298 33812 S264 E D G R S L L S Q M L H Y D P
Dog Lupus familis XP_856049 298 33839 S264 E D G R S L L S Q M L H Y D P
Cat Felis silvestris
Mouse Mus musculus P97377 346 38960 S312 E D G R S L L S Q M L H Y D P
Rat Rattus norvegicus Q63699 298 33869 S264 E D G R S L L S Q M L H Y D P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P13863 303 34670 S265 E D G L D L L S K M L I Y D P
Frog Xenopus laevis P23437 297 33852 A264 E D G R D L L A Q M L Q Y D S
Zebra Danio Brachydanio rerio NP_998571 298 34001 G264 E D G R D L L G Q M L T Y D P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P23573 314 35870 M267 A H E L I M S M L C Y D P N L
Honey Bee Apis mellifera XP_393450 299 34033 L263 S D A K D L L L K L L T Y D P
Nematode Worm Caenorhab. elegans P34556 332 38277 D283 T G K H L L D D T A F S L L E
Sea Urchin Strong. purpuratus XP_790847 299 34142 K264 K D G K D L L K S M L C Y E P
Poplar Tree Populus trichocarpa XP_002306004 294 33768 K258 T V V P T L E K A G V D L L S
Maize Zea mays P23111 294 33816 P258 T V V P N L D P A G L D L L S
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P24100 294 34012 P258 T F V P N L D P D G V D L L S
Baker's Yeast Sacchar. cerevisiae P00546 298 34043 D265 S Q V V P S L D P R G I D L L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 69.8 99.6 98.9 N.A. 85.2 98.6 N.A. N.A. 65.3 88.9 90.2 N.A. 62.7 69.9 56.9 75.9
Protein Similarity: 100 79.6 99.6 99.6 N.A. 85.8 99.6 N.A. N.A. 77.8 94.9 94.9 N.A. 74.8 82.2 69.8 88.6
P-Site Identity: 100 60 100 100 N.A. 100 100 N.A. N.A. 73.3 73.3 80 N.A. 0 46.6 6.6 53.3
P-Site Similarity: 100 73.3 100 100 N.A. 100 100 N.A. N.A. 80 80 80 N.A. 13.3 66.6 6.6 73.3
Percent
Protein Identity: 66.4 66.7 N.A. 67.1 62.4 N.A.
Protein Similarity: 83.2 82.2 N.A. 81.5 79.1 N.A.
P-Site Identity: 6.6 13.3 N.A. 6.6 6.6 N.A.
P-Site Similarity: 20 20 N.A. 20 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 6 0 6 0 0 0 0 6 12 6 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 6 0 6 0 0 0 % C
% Asp: 0 59 0 0 36 0 18 12 6 0 0 24 6 59 0 % D
% Glu: 48 6 6 0 0 0 6 0 0 0 0 0 0 6 6 % E
% Phe: 0 6 0 0 0 0 0 0 0 0 6 0 0 0 0 % F
% Gly: 0 6 59 0 0 0 0 6 0 18 6 0 0 0 0 % G
% His: 0 6 0 6 0 0 0 0 0 0 0 30 0 0 0 % H
% Ile: 0 0 0 0 6 0 0 0 0 0 0 12 0 0 0 % I
% Lys: 6 0 6 12 0 0 0 12 12 0 0 0 0 0 0 % K
% Leu: 0 0 0 12 6 89 71 6 6 12 71 0 24 30 12 % L
% Met: 0 0 0 0 0 6 0 12 0 53 0 0 0 0 0 % M
% Asn: 0 0 0 0 12 0 0 0 0 0 0 0 0 6 0 % N
% Pro: 6 0 0 18 6 0 0 12 6 0 0 0 6 0 59 % P
% Gln: 0 6 0 0 0 0 0 0 48 0 0 12 0 0 0 % Q
% Arg: 0 0 0 48 0 0 0 0 0 6 0 0 0 0 0 % R
% Ser: 12 0 0 0 30 6 6 36 6 0 0 6 0 0 24 % S
% Thr: 24 0 0 0 6 0 0 0 6 0 0 12 0 0 0 % T
% Val: 0 12 24 6 0 0 0 0 0 0 12 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 6 0 65 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _