KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK2
All Species:
42.42
Human Site:
S276
Identified Species:
58.33
UniProt:
P24941
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P24941
NP_001789.2
298
33930
S276
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
Chimpanzee
Pan troglodytes
XP_523720
325
36841
T296
Y
D
P
S
Q
R
I
T
A
K
T
A
L
A
H
Rhesus Macaque
Macaca mulatta
XP_001113345
298
33812
S276
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
Dog
Lupus familis
XP_856049
298
33839
S276
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
Cat
Felis silvestris
Mouse
Mus musculus
P97377
346
38960
S324
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
Rat
Rattus norvegicus
Q63699
298
33869
S276
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P13863
303
34670
S277
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
Frog
Xenopus laevis
P23437
297
33852
S276
Y
D
S
N
K
R
I
S
A
K
V
A
L
T
H
Zebra Danio
Brachydanio rerio
NP_998571
298
34001
S276
Y
D
P
N
K
R
I
S
A
K
N
A
L
V
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P23573
314
35870
K279
P
N
L
R
I
S
A
K
D
A
L
Q
H
A
Y
Honey Bee
Apis mellifera
XP_393450
299
34033
T275
Y
D
P
N
Q
R
I
T
A
K
K
G
L
S
H
Nematode Worm
Caenorhab. elegans
P34556
332
38277
Y295
L
L
E
G
L
L
I
Y
D
P
S
L
R
L
N
Sea Urchin
Strong. purpuratus
XP_790847
299
34142
S276
Y
E
P
D
K
R
I
S
A
K
T
G
L
S
H
Poplar Tree
Populus trichocarpa
XP_002306004
294
33768
L270
L
L
S
K
M
L
F
L
D
P
T
K
R
I
T
Maize
Zea mays
P23111
294
33816
Y270
L
L
S
K
M
L
R
Y
E
P
S
K
R
I
T
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
M270
L
L
S
K
M
L
L
M
D
P
T
K
R
I
N
Baker's Yeast
Sacchar. cerevisiae
P00546
298
34043
A277
D
L
L
D
K
L
L
A
Y
D
P
I
N
R
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
69.8
99.6
98.9
N.A.
85.2
98.6
N.A.
N.A.
65.3
88.9
90.2
N.A.
62.7
69.9
56.9
75.9
Protein Similarity:
100
79.6
99.6
99.6
N.A.
85.8
99.6
N.A.
N.A.
77.8
94.9
94.9
N.A.
74.8
82.2
69.8
88.6
P-Site Identity:
100
73.3
100
100
N.A.
100
100
N.A.
N.A.
73.3
80
86.6
N.A.
6.6
66.6
6.6
66.6
P-Site Similarity:
100
93.3
100
100
N.A.
100
100
N.A.
N.A.
73.3
80
86.6
N.A.
20
86.6
20
86.6
Percent
Protein Identity:
66.4
66.7
N.A.
67.1
62.4
N.A.
Protein Similarity:
83.2
82.2
N.A.
81.5
79.1
N.A.
P-Site Identity:
0
0
N.A.
0
6.6
N.A.
P-Site Similarity:
0
6.6
N.A.
13.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
6
0
0
6
6
59
6
30
53
0
42
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
6
59
0
12
0
0
0
0
24
6
0
0
0
0
0
% D
% Glu:
0
6
6
0
0
0
0
0
6
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
6
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
6
0
0
0
0
6
0
0
12
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
6
0
65
% H
% Ile:
0
0
0
0
6
0
71
0
0
0
0
6
0
18
6
% I
% Lys:
0
0
0
18
59
0
0
6
0
65
6
18
0
0
0
% K
% Leu:
24
30
12
0
6
30
12
6
0
0
6
6
65
6
0
% L
% Met:
0
0
0
0
18
0
0
6
0
0
6
0
0
0
0
% M
% Asn:
0
6
0
48
0
0
0
0
0
0
6
0
6
6
12
% N
% Pro:
6
0
59
0
0
0
0
0
0
24
6
0
0
0
0
% P
% Gln:
0
0
0
0
12
0
0
0
0
0
0
6
0
0
0
% Q
% Arg:
0
0
0
6
0
65
6
0
0
0
0
0
24
6
0
% R
% Ser:
0
0
24
6
0
6
0
53
0
0
12
0
0
12
0
% S
% Thr:
0
0
0
0
0
0
0
12
0
0
24
0
0
6
12
% T
% Val:
0
0
0
0
0
0
0
0
0
0
6
0
0
6
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
65
0
0
0
0
0
0
12
6
0
0
0
0
0
6
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _