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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK2
All Species:
22.73
Human Site:
Y179
Identified Species:
31.25
UniProt:
P24941
Number Species:
16
Phosphosite Substitution
Charge Score:
0.19
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P24941
NP_001789.2
298
33930
Y179
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
Chimpanzee
Pan troglodytes
XP_523720
325
36841
F199
E
I
L
L
G
S
K
F
Y
T
T
A
V
D
I
Rhesus Macaque
Macaca mulatta
XP_001113345
298
33812
Y179
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
Dog
Lupus familis
XP_856049
298
33839
Y179
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
Cat
Felis silvestris
Mouse
Mus musculus
P97377
346
38960
E227
C
P
L
C
S
Y
L
E
V
A
A
S
Q
G
G
Rat
Rattus norvegicus
Q63699
298
33869
Y179
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P13863
303
34670
L180
E
V
L
L
G
S
A
L
Y
S
T
P
V
D
I
Frog
Xenopus laevis
P23437
297
33852
F179
E
I
L
L
G
C
K
F
Y
S
T
A
V
D
I
Zebra Danio
Brachydanio rerio
NP_998571
298
34001
Y179
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P23573
314
35870
F182
E
I
L
L
G
T
K
F
Y
S
T
G
V
D
I
Honey Bee
Apis mellifera
XP_393450
299
34033
L178
E
I
L
L
G
T
K
L
Y
S
N
A
V
D
V
Nematode Worm
Caenorhab. elegans
P34556
332
38277
R198
E
I
L
M
G
A
Q
R
Y
S
M
G
V
D
M
Sea Urchin
Strong. purpuratus
XP_790847
299
34142
Y179
E
I
L
L
G
C
R
Y
Y
S
T
A
V
D
I
Poplar Tree
Populus trichocarpa
XP_002306004
294
33768
E173
T
L
W
Y
R
A
P
E
I
L
L
G
S
R
H
Maize
Zea mays
P23111
294
33816
E173
T
L
W
Y
R
A
P
E
I
L
L
G
A
R
Q
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
E173
T
L
W
Y
R
A
P
E
I
L
L
G
S
H
H
Baker's Yeast
Sacchar. cerevisiae
P00546
298
34043
P180
V
T
L
W
Y
R
A
P
E
V
L
L
G
G
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
69.8
99.6
98.9
N.A.
85.2
98.6
N.A.
N.A.
65.3
88.9
90.2
N.A.
62.7
69.9
56.9
75.9
Protein Similarity:
100
79.6
99.6
99.6
N.A.
85.8
99.6
N.A.
N.A.
77.8
94.9
94.9
N.A.
74.8
82.2
69.8
88.6
P-Site Identity:
100
80
100
100
N.A.
6.6
100
N.A.
N.A.
66.6
93.3
100
N.A.
80
73.3
53.3
93.3
P-Site Similarity:
100
93.3
100
100
N.A.
20
100
N.A.
N.A.
73.3
100
100
N.A.
86.6
80
73.3
100
Percent
Protein Identity:
66.4
66.7
N.A.
67.1
62.4
N.A.
Protein Similarity:
83.2
82.2
N.A.
81.5
79.1
N.A.
P-Site Identity:
0
0
N.A.
0
6.6
N.A.
P-Site Similarity:
6.6
6.6
N.A.
6.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
24
12
0
0
6
6
53
6
0
0
% A
% Cys:
6
0
0
6
0
42
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
71
0
% D
% Glu:
71
0
0
0
0
0
0
24
6
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
18
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
71
0
0
0
0
0
0
30
6
12
6
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
6
12
% H
% Ile:
0
65
0
0
0
0
0
0
18
0
0
0
0
0
59
% I
% Lys:
0
0
0
0
0
0
53
0
0
0
0
0
0
0
6
% K
% Leu:
0
18
83
65
0
0
6
12
0
18
24
6
0
0
0
% L
% Met:
0
0
0
6
0
0
0
0
0
0
6
0
0
0
6
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
6
0
0
0
0
% N
% Pro:
0
6
0
0
0
0
18
6
0
0
0
6
0
0
0
% P
% Gln:
0
0
0
0
0
0
6
0
0
0
0
0
6
0
6
% Q
% Arg:
0
0
0
0
18
6
6
6
0
0
0
0
0
12
0
% R
% Ser:
0
0
0
0
6
12
0
0
0
65
0
6
12
0
0
% S
% Thr:
18
6
0
0
0
12
0
0
0
6
59
0
0
0
0
% T
% Val:
6
6
0
0
0
0
0
0
6
6
0
0
71
0
6
% V
% Trp:
0
0
18
6
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
18
6
6
0
36
71
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _