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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HRH2
All Species:
10.61
Human Site:
S220
Identified Species:
21.21
UniProt:
P25021
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P25021
NP_071640.1
359
40098
S220
A
K
R
I
N
H
I
S
S
W
K
A
A
T
I
Chimpanzee
Pan troglodytes
XP_001162258
428
48268
Q245
S
R
P
Q
S
A
D
Q
H
S
T
H
R
M
R
Rhesus Macaque
Macaca mulatta
Q28509
415
46453
R259
G
R
T
G
H
G
L
R
R
S
S
K
F
C
L
Dog
Lupus familis
XP_546225
359
40183
G220
A
K
R
I
H
H
M
G
S
W
K
A
A
T
I
Cat
Felis silvestris
Mouse
Mus musculus
P97292
358
40361
S219
A
K
R
I
N
H
I
S
S
W
K
A
A
T
I
Rat
Rattus norvegicus
P25102
358
40235
S219
A
K
R
I
N
H
I
S
S
W
K
A
A
T
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_425208
351
39363
N215
H
T
W
C
C
S
S
N
G
P
M
P
P
M
V
Frog
Xenopus laevis
O42574
385
43291
D237
Q
K
Q
M
K
K
I
D
K
C
E
G
R
F
S
Zebra Danio
Brachydanio rerio
NP_001038803
410
45665
Q257
R
R
G
S
T
S
S
Q
G
V
T
I
L
T
L
Tiger Blowfish
Takifugu rubipres
P53454
463
51077
S260
R
A
S
T
H
D
E
S
A
L
K
T
S
F
K
Fruit Fly
Dros. melanogaster
Q9VCZ3
508
56837
Q336
R
P
S
I
Q
V
E
Q
S
T
I
S
T
M
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_792332
363
40947
P212
G
L
L
L
F
Y
L
P
L
T
V
M
C
C
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
34.8
31
86.9
N.A.
84.9
86
N.A.
N.A.
57
33.7
45.1
29.5
28.9
N.A.
N.A.
40.2
Protein Similarity:
100
50
50.3
92.7
N.A.
90.2
89.9
N.A.
N.A.
69.3
51.6
60.7
48.6
43.1
N.A.
N.A.
57.3
P-Site Identity:
100
0
0
80
N.A.
100
100
N.A.
N.A.
0
13.3
6.6
13.3
13.3
N.A.
N.A.
0
P-Site Similarity:
100
20
26.6
93.3
N.A.
100
100
N.A.
N.A.
13.3
33.3
20
33.3
20
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
34
9
0
0
0
9
0
0
9
0
0
34
34
0
0
% A
% Cys:
0
0
0
9
9
0
0
0
0
9
0
0
9
17
0
% C
% Asp:
0
0
0
0
0
9
9
9
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
17
0
0
0
9
0
0
0
0
% E
% Phe:
0
0
0
0
9
0
0
0
0
0
0
0
9
17
0
% F
% Gly:
17
0
9
9
0
9
0
9
17
0
0
9
0
0
0
% G
% His:
9
0
0
0
25
34
0
0
9
0
0
9
0
0
0
% H
% Ile:
0
0
0
42
0
0
34
0
0
0
9
9
0
0
34
% I
% Lys:
0
42
0
0
9
9
0
0
9
0
42
9
0
0
9
% K
% Leu:
0
9
9
9
0
0
17
0
9
9
0
0
9
0
25
% L
% Met:
0
0
0
9
0
0
9
0
0
0
9
9
0
25
0
% M
% Asn:
0
0
0
0
25
0
0
9
0
0
0
0
0
0
0
% N
% Pro:
0
9
9
0
0
0
0
9
0
9
0
9
9
0
0
% P
% Gln:
9
0
9
9
9
0
0
25
0
0
0
0
0
0
0
% Q
% Arg:
25
25
34
0
0
0
0
9
9
0
0
0
17
0
17
% R
% Ser:
9
0
17
9
9
17
17
34
42
17
9
9
9
0
9
% S
% Thr:
0
9
9
9
9
0
0
0
0
17
17
9
9
42
0
% T
% Val:
0
0
0
0
0
9
0
0
0
9
9
0
0
0
9
% V
% Trp:
0
0
9
0
0
0
0
0
0
34
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _