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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: APC All Species: 14.55
Human Site: S1189 Identified Species: 26.67
UniProt: P25054 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P25054 NP_000029.2 2843 311646 S1189 K Y A T D I P S S Q K Q S F S
Chimpanzee Pan troglodytes XP_001143509 2844 311637 S1189 K Y A T D I P S S Q K Q S F S
Rhesus Macaque Macaca mulatta XP_001095216 2303 243755 N695 G S A A A L R N L L A H R P A
Dog Lupus familis XP_536285 2273 247246 A665 T Q H H P S S A Q S R N G Q T
Cat Felis silvestris
Mouse Mus musculus Q61315 2845 311071 S1188 K Y A T D I S S S Q K P S F S
Rat Rattus norvegicus P70478 2842 310514 S1186 L K Y A T D I S S S Q K P S F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511806 2844 309621 S1194 Y A S D V P P S S Q K P S F S
Chicken Gallus gallus XP_001233411 2232 244958 S624 V G T L T Y R S Q T N T L A I
Frog Xenopus laevis P70039 2829 310863 A1195 S T D V P S S A Q K P S F P Y
Zebra Danio Brachydanio rerio NP_001137312 2754 301074 T1133 E E Q L E E Q T P S Y S M K Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477152 2417 261266 G809 L D I S G P A G G Q K S T I T
Honey Bee Apis mellifera XP_624558 2760 306907 S1150 Y P N N G V N S Y V T S A L K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783363 3212 346162 R1318 E T P L V F S R C S S V C S L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 35 74.2 N.A. 90.4 90.1 N.A. 86.7 67.1 75 68 N.A. 23.8 22.8 N.A. 29.1
Protein Similarity: 100 99.5 49.4 76.1 N.A. 94.2 94.3 N.A. 92.7 72.2 84 78.2 N.A. 41 42 N.A. 45.1
P-Site Identity: 100 100 6.6 0 N.A. 86.6 13.3 N.A. 53.3 6.6 0 0 N.A. 13.3 6.6 N.A. 0
P-Site Similarity: 100 100 26.6 20 N.A. 86.6 26.6 N.A. 60 6.6 13.3 20 N.A. 33.3 20 N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 31 16 8 0 8 16 0 0 8 0 8 8 8 % A
% Cys: 0 0 0 0 0 0 0 0 8 0 0 0 8 0 0 % C
% Asp: 0 8 8 8 24 8 0 0 0 0 0 0 0 0 0 % D
% Glu: 16 8 0 0 8 8 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 8 0 0 0 0 0 0 8 31 8 % F
% Gly: 8 8 0 0 16 0 0 8 8 0 0 0 8 0 0 % G
% His: 0 0 8 8 0 0 0 0 0 0 0 8 0 0 0 % H
% Ile: 0 0 8 0 0 24 8 0 0 0 0 0 0 8 8 % I
% Lys: 24 8 0 0 0 0 0 0 0 8 39 8 0 8 8 % K
% Leu: 16 0 0 24 0 8 0 0 8 8 0 0 8 8 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % M
% Asn: 0 0 8 8 0 0 8 8 0 0 8 8 0 0 0 % N
% Pro: 0 8 8 0 16 16 24 0 8 0 8 16 8 16 0 % P
% Gln: 0 8 8 0 0 0 8 0 24 39 8 16 0 8 0 % Q
% Arg: 0 0 0 0 0 0 16 8 0 0 8 0 8 0 0 % R
% Ser: 8 8 8 8 0 16 31 54 39 31 8 31 31 16 31 % S
% Thr: 8 16 8 24 16 0 0 8 0 8 8 8 8 0 16 % T
% Val: 8 0 0 8 16 8 0 0 0 8 0 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 16 24 8 0 0 8 0 0 8 0 8 0 0 0 16 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _