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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: APC All Species: 17.88
Human Site: S1212 Identified Species: 32.78
UniProt: P25054 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P25054 NP_000029.2 2843 311646 S1212 S S K T E H M S S S S E N T S
Chimpanzee Pan troglodytes XP_001143509 2844 311637 S1212 S S K T E H M S S S S E N T S
Rhesus Macaque Macaca mulatta XP_001095216 2303 243755 P718 V S P G S C V P S L Y V R K Q
Dog Lupus familis XP_536285 2273 247246 I688 P S I N Q E T I Q T Y C V E D
Cat Felis silvestris
Mouse Mus musculus Q61315 2845 311071 S1211 S T K P E H L S P S S E N T A
Rat Rattus norvegicus P70478 2842 310514 N1209 Q G T K T E H N S P S S E A A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511806 2844 309621 S1217 S A K A E H I S T S N G N V S
Chicken Gallus gallus XP_001233411 2232 244958 A647 R N V S S L I A T N E D H R Q
Frog Xenopus laevis P70039 2829 310863 S1218 P K K E Q V S S N S N T P T P
Zebra Danio Brachydanio rerio NP_001137312 2754 301074 Y1156 P I D Y S L K Y S E A P S K K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477152 2417 261266 L832 K S E G Q E I L L I L D D S V
Honey Bee Apis mellifera XP_624558 2760 306907 T1173 E F E L K G D T R N M P Y I L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783363 3212 346162 Y1341 C D D V S S I Y T N S R A A S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 35 74.2 N.A. 90.4 90.1 N.A. 86.7 67.1 75 68 N.A. 23.8 22.8 N.A. 29.1
Protein Similarity: 100 99.5 49.4 76.1 N.A. 94.2 94.3 N.A. 92.7 72.2 84 78.2 N.A. 41 42 N.A. 45.1
P-Site Identity: 100 100 13.3 6.6 N.A. 66.6 13.3 N.A. 53.3 0 26.6 6.6 N.A. 6.6 0 N.A. 13.3
P-Site Similarity: 100 100 20 20 N.A. 86.6 26.6 N.A. 80 53.3 46.6 20 N.A. 46.6 26.6 N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 8 0 0 0 8 0 0 8 0 8 16 16 % A
% Cys: 8 0 0 0 0 8 0 0 0 0 0 8 0 0 0 % C
% Asp: 0 8 16 0 0 0 8 0 0 0 0 16 8 0 8 % D
% Glu: 8 0 16 8 31 24 0 0 0 8 8 24 8 8 0 % E
% Phe: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 8 0 16 0 8 0 0 0 0 0 8 0 0 0 % G
% His: 0 0 0 0 0 31 8 0 0 0 0 0 8 0 0 % H
% Ile: 0 8 8 0 0 0 31 8 0 8 0 0 0 8 0 % I
% Lys: 8 8 39 8 8 0 8 0 0 0 0 0 0 16 8 % K
% Leu: 0 0 0 8 0 16 8 8 8 8 8 0 0 0 8 % L
% Met: 0 0 0 0 0 0 16 0 0 0 8 0 0 0 0 % M
% Asn: 0 8 0 8 0 0 0 8 8 24 16 0 31 0 0 % N
% Pro: 24 0 8 8 0 0 0 8 8 8 0 16 8 0 8 % P
% Gln: 8 0 0 0 24 0 0 0 8 0 0 0 0 0 16 % Q
% Arg: 8 0 0 0 0 0 0 0 8 0 0 8 8 8 0 % R
% Ser: 31 39 0 8 31 8 8 39 39 39 39 8 8 8 31 % S
% Thr: 0 8 8 16 8 0 8 8 24 8 0 8 0 31 0 % T
% Val: 8 0 8 8 0 8 8 0 0 0 0 8 8 8 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 0 0 0 16 0 0 16 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _