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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: APC All Species: 15.45
Human Site: S1214 Identified Species: 28.33
UniProt: P25054 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P25054 NP_000029.2 2843 311646 S1214 K T E H M S S S S E N T S T P
Chimpanzee Pan troglodytes XP_001143509 2844 311637 S1214 K T E H M S S S S E N T S T P
Rhesus Macaque Macaca mulatta XP_001095216 2303 243755 L720 P G S C V P S L Y V R K Q R A
Dog Lupus familis XP_536285 2273 247246 T690 I N Q E T I Q T Y C V E D T P
Cat Felis silvestris
Mouse Mus musculus Q61315 2845 311071 S1213 K P E H L S P S S E N T A V P
Rat Rattus norvegicus P70478 2842 310514 P1211 T K T E H N S P S S E A A S A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511806 2844 309621 S1219 K A E H I S T S N G N V S T S
Chicken Gallus gallus XP_001233411 2232 244958 N649 V S S L I A T N E D H R Q I L
Frog Xenopus laevis P70039 2829 310863 S1220 K E Q V S S N S N T P T P S P
Zebra Danio Brachydanio rerio NP_001137312 2754 301074 E1158 D Y S L K Y S E A P S K K G M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477152 2417 261266 I834 E G Q E I L L I L D D S V K C
Honey Bee Apis mellifera XP_624558 2760 306907 N1175 E L K G D T R N M P Y I L N I
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783363 3212 346162 N1343 D V S S I Y T N S R A A S G F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 35 74.2 N.A. 90.4 90.1 N.A. 86.7 67.1 75 68 N.A. 23.8 22.8 N.A. 29.1
Protein Similarity: 100 99.5 49.4 76.1 N.A. 94.2 94.3 N.A. 92.7 72.2 84 78.2 N.A. 41 42 N.A. 45.1
P-Site Identity: 100 100 6.6 13.3 N.A. 66.6 13.3 N.A. 53.3 0 33.3 6.6 N.A. 0 0 N.A. 13.3
P-Site Similarity: 100 100 13.3 26.6 N.A. 80 33.3 N.A. 73.3 46.6 60 20 N.A. 40 26.6 N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 0 8 0 0 8 0 8 16 16 0 16 % A
% Cys: 0 0 0 8 0 0 0 0 0 8 0 0 0 0 8 % C
% Asp: 16 0 0 0 8 0 0 0 0 16 8 0 8 0 0 % D
% Glu: 16 8 31 24 0 0 0 8 8 24 8 8 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % F
% Gly: 0 16 0 8 0 0 0 0 0 8 0 0 0 16 0 % G
% His: 0 0 0 31 8 0 0 0 0 0 8 0 0 0 0 % H
% Ile: 8 0 0 0 31 8 0 8 0 0 0 8 0 8 8 % I
% Lys: 39 8 8 0 8 0 0 0 0 0 0 16 8 8 0 % K
% Leu: 0 8 0 16 8 8 8 8 8 0 0 0 8 0 8 % L
% Met: 0 0 0 0 16 0 0 0 8 0 0 0 0 0 8 % M
% Asn: 0 8 0 0 0 8 8 24 16 0 31 0 0 8 0 % N
% Pro: 8 8 0 0 0 8 8 8 0 16 8 0 8 0 39 % P
% Gln: 0 0 24 0 0 0 8 0 0 0 0 0 16 0 0 % Q
% Arg: 0 0 0 0 0 0 8 0 0 8 8 8 0 8 0 % R
% Ser: 0 8 31 8 8 39 39 39 39 8 8 8 31 16 8 % S
% Thr: 8 16 8 0 8 8 24 8 0 8 0 31 0 31 0 % T
% Val: 8 8 0 8 8 0 0 0 0 8 8 8 8 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 0 16 0 0 16 0 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _