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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: APC All Species: 20.91
Human Site: S1587 Identified Species: 38.33
UniProt: P25054 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P25054 NP_000029.2 2843 311646 S1587 I S A M P T K S S R K A K K P
Chimpanzee Pan troglodytes XP_001143509 2844 311637 S1587 I S A M P T K S S C K A K K P
Rhesus Macaque Macaca mulatta XP_001095216 2303 243755 S1074 L S L S R C S S L S S L S S A
Dog Lupus familis XP_536285 2273 247246 Y1044 K P S Q L P V Y K L L P S Q N
Cat Felis silvestris
Mouse Mus musculus Q61315 2845 311071 S1585 I S A M P T K S S R K A K K L
Rat Rattus norvegicus P70478 2842 310514 S1585 I S A M P T K S S R K A K K L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511806 2844 309621 S1592 I S A M P T K S S R K A K K P
Chicken Gallus gallus XP_001233411 2232 244958 V1003 E P F I Q K D V E L R I M P P
Frog Xenopus laevis P70039 2829 310863 S1589 S A M P R K P S R K N K K V P
Zebra Danio Brachydanio rerio NP_001137312 2754 301074 E1512 H S I E A E P E M E D M H E P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477152 2417 261266 H1188 G Q A Q M Y A H Q L S D D V S
Honey Bee Apis mellifera XP_624558 2760 306907 S1530 D P D A M I A S L D R L T A T
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783363 3212 346162 L1883 R A D S L S S L S C D E E D A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 35 74.2 N.A. 90.4 90.1 N.A. 86.7 67.1 75 68 N.A. 23.8 22.8 N.A. 29.1
Protein Similarity: 100 99.5 49.4 76.1 N.A. 94.2 94.3 N.A. 92.7 72.2 84 78.2 N.A. 41 42 N.A. 45.1
P-Site Identity: 100 93.3 13.3 0 N.A. 93.3 93.3 N.A. 100 6.6 20 13.3 N.A. 6.6 6.6 N.A. 6.6
P-Site Similarity: 100 93.3 20 13.3 N.A. 93.3 93.3 N.A. 100 20 33.3 20 N.A. 6.6 13.3 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 16 47 8 8 0 16 0 0 0 0 39 0 8 16 % A
% Cys: 0 0 0 0 0 8 0 0 0 16 0 0 0 0 0 % C
% Asp: 8 0 16 0 0 0 8 0 0 8 16 8 8 8 0 % D
% Glu: 8 0 0 8 0 8 0 8 8 8 0 8 8 8 0 % E
% Phe: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 8 0 0 0 0 0 0 8 0 0 0 0 8 0 0 % H
% Ile: 39 0 8 8 0 8 0 0 0 0 0 8 0 0 0 % I
% Lys: 8 0 0 0 0 16 39 0 8 8 39 8 47 39 0 % K
% Leu: 8 0 8 0 16 0 0 8 16 24 8 16 0 0 16 % L
% Met: 0 0 8 39 16 0 0 0 8 0 0 8 8 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 8 % N
% Pro: 0 24 0 8 39 8 16 0 0 0 0 8 0 8 47 % P
% Gln: 0 8 0 16 8 0 0 0 8 0 0 0 0 8 0 % Q
% Arg: 8 0 0 0 16 0 0 0 8 31 16 0 0 0 0 % R
% Ser: 8 54 8 16 0 8 16 62 47 8 16 0 16 8 8 % S
% Thr: 0 0 0 0 0 39 0 0 0 0 0 0 8 0 8 % T
% Val: 0 0 0 0 0 0 8 8 0 0 0 0 0 16 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 8 0 8 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _