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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: APC All Species: 10.91
Human Site: S2054 Identified Species: 20
UniProt: P25054 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P25054 NP_000029.2 2843 311646 S2054 M P K K K K P S R L K G D N E
Chimpanzee Pan troglodytes XP_001143509 2844 311637 S2055 M P K K K K P S R L K G D H E
Rhesus Macaque Macaca mulatta XP_001095216 2303 243755 P1521 N D S D E E P P A A A P T P T
Dog Lupus familis XP_536285 2273 247246 E1491 S R L K G D T E K H S P R N M
Cat Felis silvestris
Mouse Mus musculus Q61315 2845 311071 R2054 P K K K R P S R L K S E S E K
Rat Rattus norvegicus P70478 2842 310514 R2054 P K K R R P S R L K G E G E W
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511806 2844 309621 S2055 M P K K K K P S R L K G D N E
Chicken Gallus gallus XP_001233411 2232 244958 I1450 S L S S L S D I D Q E N N N N
Frog Xenopus laevis P70039 2829 310863 A2043 L Q E C I S S A M P K K R K P
Zebra Danio Brachydanio rerio NP_001137312 2754 301074 T1964 K A F H V E D T P V C F S R N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477152 2417 261266 S1635 E T C I S G A S E K H K D P D
Honey Bee Apis mellifera XP_624558 2760 306907 P1978 Q T Q V L E N P F P D M N Q D
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783363 3212 346162 N2424 P E Q T P E M N P V S G D E K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 35 74.2 N.A. 90.4 90.1 N.A. 86.7 67.1 75 68 N.A. 23.8 22.8 N.A. 29.1
Protein Similarity: 100 99.5 49.4 76.1 N.A. 94.2 94.3 N.A. 92.7 72.2 84 78.2 N.A. 41 42 N.A. 45.1
P-Site Identity: 100 93.3 6.6 13.3 N.A. 13.3 6.6 N.A. 100 6.6 6.6 0 N.A. 13.3 0 N.A. 13.3
P-Site Similarity: 100 100 20 20 N.A. 26.6 20 N.A. 100 20 26.6 20 N.A. 20 26.6 N.A. 46.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 0 0 8 8 8 8 8 0 0 0 0 % A
% Cys: 0 0 8 8 0 0 0 0 0 0 8 0 0 0 0 % C
% Asp: 0 8 0 8 0 8 16 0 8 0 8 0 39 0 16 % D
% Glu: 8 8 8 0 8 31 0 8 8 0 8 16 0 24 24 % E
% Phe: 0 0 8 0 0 0 0 0 8 0 0 8 0 0 0 % F
% Gly: 0 0 0 0 8 8 0 0 0 0 8 31 8 0 0 % G
% His: 0 0 0 8 0 0 0 0 0 8 8 0 0 8 0 % H
% Ile: 0 0 0 8 8 0 0 8 0 0 0 0 0 0 0 % I
% Lys: 8 16 39 39 24 24 0 0 8 24 31 16 0 8 16 % K
% Leu: 8 8 8 0 16 0 0 0 16 24 0 0 0 0 0 % L
% Met: 24 0 0 0 0 0 8 0 8 0 0 8 0 0 8 % M
% Asn: 8 0 0 0 0 0 8 8 0 0 0 8 16 31 16 % N
% Pro: 24 24 0 0 8 16 31 16 16 16 0 16 0 16 8 % P
% Gln: 8 8 16 0 0 0 0 0 0 8 0 0 0 8 0 % Q
% Arg: 0 8 0 8 16 0 0 16 24 0 0 0 16 8 0 % R
% Ser: 16 0 16 8 8 16 24 31 0 0 24 0 16 0 0 % S
% Thr: 0 16 0 8 0 0 8 8 0 0 0 0 8 0 8 % T
% Val: 0 0 0 8 8 0 0 0 0 16 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _