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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: APC All Species: 18.79
Human Site: S2290 Identified Species: 34.44
UniProt: P25054 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P25054 NP_000029.2 2843 311646 S2290 S P V A R Q T S Q I G G S S K
Chimpanzee Pan troglodytes XP_001143509 2844 311637 S2291 S P V A R Q T S Q I G G T S K
Rhesus Macaque Macaca mulatta XP_001095216 2303 243755 G1757 A R R P E K R G A A S A K T S
Dog Lupus familis XP_536285 2273 247246 K1727 P Q P A G A N K G P S R S G S
Cat Felis silvestris
Mouse Mus musculus Q61315 2845 311071 S2290 S P I T R Q T S Q I S G S N K
Rat Rattus norvegicus P70478 2842 310514 S2290 S P I T R Q T S H I S G S N K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511806 2844 309621 S2291 S P V N R Q P S Q A G G S S K
Chicken Gallus gallus XP_001233411 2232 244958 S1686 G L N Q G G S S K G P S R S G
Frog Xenopus laevis P70039 2829 310863 E2279 G T K P L K S E L V Y G S R P
Zebra Danio Brachydanio rerio NP_001137312 2754 301074 P2200 S P V P K K P P P R G Q M S K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477152 2417 261266 A1871 F A R K M F P A N L V A R R A
Honey Bee Apis mellifera XP_624558 2760 306907 N2214 R D P S N D S N A T D K S D P
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783363 3212 346162 S2660 N K P A S R P S S A E G S R S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 35 74.2 N.A. 90.4 90.1 N.A. 86.7 67.1 75 68 N.A. 23.8 22.8 N.A. 29.1
Protein Similarity: 100 99.5 49.4 76.1 N.A. 94.2 94.3 N.A. 92.7 72.2 84 78.2 N.A. 41 42 N.A. 45.1
P-Site Identity: 100 93.3 0 13.3 N.A. 73.3 66.6 N.A. 80 13.3 13.3 40 N.A. 0 6.6 N.A. 26.6
P-Site Similarity: 100 100 20 13.3 N.A. 86.6 80 N.A. 80 26.6 33.3 53.3 N.A. 13.3 26.6 N.A. 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 0 31 0 8 0 8 16 24 0 16 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 0 0 0 8 0 0 0 0 8 0 0 8 0 % D
% Glu: 0 0 0 0 8 0 0 8 0 0 8 0 0 0 0 % E
% Phe: 8 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % F
% Gly: 16 0 0 0 16 8 0 8 8 8 31 54 0 8 8 % G
% His: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % H
% Ile: 0 0 16 0 0 0 0 0 0 31 0 0 0 0 0 % I
% Lys: 0 8 8 8 8 24 0 8 8 0 0 8 8 0 47 % K
% Leu: 0 8 0 0 8 0 0 0 8 8 0 0 0 0 0 % L
% Met: 0 0 0 0 8 0 0 0 0 0 0 0 8 0 0 % M
% Asn: 8 0 8 8 8 0 8 8 8 0 0 0 0 16 0 % N
% Pro: 8 47 24 24 0 0 31 8 8 8 8 0 0 0 16 % P
% Gln: 0 8 0 8 0 39 0 0 31 0 0 8 0 0 0 % Q
% Arg: 8 8 16 0 39 8 8 0 0 8 0 8 16 24 0 % R
% Ser: 47 0 0 8 8 0 24 54 8 0 31 8 62 39 24 % S
% Thr: 0 8 0 16 0 0 31 0 0 8 0 0 8 8 0 % T
% Val: 0 0 31 0 0 0 0 0 0 8 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _