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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
APC
All Species:
12.42
Human Site:
S274
Identified Species:
22.78
UniProt:
P25054
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P25054
NP_000029.2
2843
311646
S274
G
E
I
N
M
A
T
S
G
N
G
Q
G
S
T
Chimpanzee
Pan troglodytes
XP_001143509
2844
311637
S274
G
E
I
N
M
A
T
S
G
N
G
Q
G
S
T
Rhesus Macaque
Macaca mulatta
XP_001095216
2303
243755
Dog
Lupus familis
XP_536285
2273
247246
Cat
Felis silvestris
Mouse
Mus musculus
Q61315
2845
311071
S272
A
E
S
N
T
A
A
S
S
S
G
Q
S
P
A
Rat
Rattus norvegicus
P70478
2842
310514
S272
A
E
S
N
L
A
T
S
G
S
G
Q
S
S
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511806
2844
309621
A274
A
E
I
S
M
A
T
A
G
S
G
Q
G
S
T
Chicken
Gallus gallus
XP_001233411
2232
244958
Frog
Xenopus laevis
P70039
2829
310863
V276
E
I
T
A
S
G
N
V
G
S
G
Q
G
S
S
Zebra Danio
Brachydanio rerio
NP_001137312
2754
301074
S268
A
G
A
A
A
A
A
S
V
C
S
Q
G
S
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477152
2417
261266
Honey Bee
Apis mellifera
XP_624558
2760
306907
T270
G
F
S
T
Q
Q
G
T
S
T
T
V
H
N
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783363
3212
346162
N254
G
S
G
A
G
S
G
N
G
E
L
E
T
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
35
74.2
N.A.
90.4
90.1
N.A.
86.7
67.1
75
68
N.A.
23.8
22.8
N.A.
29.1
Protein Similarity:
100
99.5
49.4
76.1
N.A.
94.2
94.3
N.A.
92.7
72.2
84
78.2
N.A.
41
42
N.A.
45.1
P-Site Identity:
100
100
0
0
N.A.
40
60
N.A.
73.3
0
33.3
33.3
N.A.
0
6.6
N.A.
20
P-Site Similarity:
100
100
0
0
N.A.
46.6
73.3
N.A.
93.3
0
46.6
33.3
N.A.
0
20
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
31
0
8
24
8
47
16
8
0
0
0
0
0
0
24
% A
% Cys:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% D
% Glu:
8
39
0
0
0
0
0
0
0
8
0
8
0
0
0
% E
% Phe:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
31
8
8
0
8
8
16
0
47
0
47
0
39
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% H
% Ile:
0
8
24
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
8
0
0
0
0
0
8
0
0
0
0
% L
% Met:
0
0
0
0
24
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
31
0
0
8
8
0
16
0
0
0
8
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% P
% Gln:
0
0
0
0
8
8
0
0
0
0
0
54
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
8
24
8
8
8
0
39
16
31
8
0
16
54
16
% S
% Thr:
0
0
8
8
8
0
31
8
0
8
8
0
8
0
24
% T
% Val:
0
0
0
0
0
0
0
8
8
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _